Search results
Nov 24, 2020 · The exact mechanisms responsible for severe manifestations of dengue virus disease are not yet fully elucidated and are likely to be multifactorial. DENV infection can have diverse presentations in different hosts, which cannot be explained by a single hypothesis alone.
Dec 15, 2021 · Potential antiviral mechanism and molecular targets of the bioactive compounds inhibiting viral entry and replication of dengue virus. Infection of virus involves various stages: In the initial steps, DENV binds to cell receptors including mannose-binding receptor (MR) and DC-SIGN (dendritic cell-specific ICAM3 grabbing nonintegrin) receptor ...
- 10.1155/2021/4224816
- 2021
- Biomed Res Int. 2021; 2021: 4224816.
Mar 8, 2023 · Antiviral agents designed based on these molecular mechanisms of action could lead to the discovery and development of novel anti-DENV therapeutics for the treatment of dengue infections.
- 10.3390/v15030705
- 2023/03
- Viruses. 2023 Mar; 15(3): 705.
Jan 15, 2023 · FcR-dependent ADE is the most common mechanism for a wide range of virus infection such as HIV, influenza A, dengue and Ebola. Cells which have FcR such as monocytes, B cells, neutrophils and macrophages are easily attached by the virus-antibody complexes because the Fc region of the antibody will bind on the cell surface with FcR which leads ...
Oct 6, 2021 · Global Health Equity. Janssen Announces Novel Mechanism of Action that Shows Promise Against Dengue in Data Published in Nature. Early-stage research suggests potential to prevent and treat all dengue serotypes. With no treatments available, dengue infects up to 400 million people each year and the pace of outbreaks is increasing. [1]
Nov 19, 2023 · It was observed that PAIgG-coated platelets go through increased clearance via Fcγ receptors expressed on mononuclear phagocytic cells. The mechanism of action of IVIGs involves the ligation of inhibitory receptors or competitive suppression of Fcγ receptors.
Apr 22, 2024 · This review aims to summarize the complex interaction between DENV and the host cellular machinery, comprising regulatory mechanisms at various molecular levels such as epigenetic modulation of the host genome, transcription of host genes, translation of viral and host mRNAs, post-transcriptional regulation of the host transcriptome, post-transl...
