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  1. Nov 24, 2020 · The pathogenesis of dengue was attributed to various viral and host factors such as non-structural protein 1 (NS1) viral antigen, DENV genome variation, subgenomic RNA, antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies and autoimmunity.

  2. Dec 15, 2021 · Potential antiviral mechanism and molecular targets of the bioactive compounds inhibiting viral entry and replication of dengue virus. Infection of virus involves various stages: In the initial steps, DENV binds to cell receptors including mannose-binding receptor (MR) and DC-SIGN (dendritic cell-specific ICAM3 grabbing nonintegrin) receptor ...

    • 10.1155/2021/4224816
    • 2021
    • Biomed Res Int. 2021; 2021: 4224816.
  3. Apr 22, 2024 · This review aims to summarize the complex interaction between DENV and the host cellular machinery, comprising regulatory mechanisms at various molecular levels such as epigenetic modulation of the host genome, transcription of host genes, translation of viral and host mRNAs, post-transcriptional regulation of the host transcriptome, post-transl...

    • Saumya Sinha
  4. Dengue NS1 antigen, cytokines such as IL-1β, TNF-α, and IL-6, lipid mediators such as platelet-activating factor (PAF), leukotrienes and prostaglandins, VEGF, chymase, tryptase, and MMP-9 are thought to contribute to endothelial dysfunction.

  5. Jan 15, 2023 · Human normally gets infected by dengue virus (DENV) through infected mosquitoes such as Aedes aegypti or Aedes albopictus (Bhatt et al., 2013). DENV will target on the dendritic cells (DCs) and macrophages during first day of infection (Kyle et al., 2007).

  6. Sep 20, 2019 · Potential mechanisms for hepatic injury involve a variety of possible insults, including direct effects of the virus or host immune response on liver cells, circulatory compromise, and/or hypoxia due to hypotension or localized vascular leakage inside the liver capsule, hepatotoxic effects of drugs such as acetaminophen or traditional herbal ...

  7. Nov 19, 2023 · It was observed that PAIgG-coated platelets go through increased clearance via Fcγ receptors expressed on mononuclear phagocytic cells. The mechanism of action of IVIGs involves the ligation of inhibitory receptors or competitive suppression of Fcγ receptors.

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