Search results
Apr 22, 2024 · HnRNPs (heterogeneous nuclear ribonucleoproteins), for instance, have been shown to regulate host mRNA expression in response to dengue infection. Modulation of these RBPs by dengue infection can impact mRNA transport and localization, potentially influencing viral replication and pathogenesis.
- Saumya Sinha
Nov 24, 2020 · The present article reviews the current concepts of the various mechanisms involved in the pathogenesis of dengue virus infection and gives a comprehensive overview of the multiple factors responsible for severe clinical manifestations of the disease.
- Puneet Bhatt, Sasidharan Pillai Sabeena, Muralidhar Varma, Govindakarnavar Arunkumar, Govindakarnava...
- 10.1007/s00284-020-02284-w
- 2021
- Curr Microbiol. 2021; 78(1): 17-32.
Dec 15, 2021 · Potential antiviral mechanism and molecular targets of the bioactive compounds inhibiting viral entry and replication of dengue virus. Infection of virus involves various stages: In the initial steps, DENV binds to cell receptors including mannose-binding receptor (MR) and DC-SIGN (dendritic cell-specific ICAM3 grabbing nonintegrin) receptor ...
- 10.1155/2021/4224816
- 2021
- Biomed Res Int. 2021; 2021: 4224816.
- Abstract
- Conclusion
- Acknowledgements
The pathogenesis of dengue virus infection is attributed to complex interplay between virus, host genes and host immune response. Host factors such as antibody-dependent enhancement (ADE), memory cross-reactive T cells, anti-DENV NS1 antibodies, autoimmunity as well as genetic factors are major determinants of disease susceptibility. NS1 protein an...
The exact mechanisms responsible for severe manifestations of dengue virus disease are not yet fully elucidated and are likely to be multifactorial. DENV infection can have diverse presentations in diferent hosts, which cannot be explained by a single hypothesis alone. The recent results of the eficacy and safety trials of the CYD-TDV tetravalent d...
None. Author’s Contributions PB, GA, and MV conceived the study. PB, SPS searched database for articles. PB, SPS, GA, and MV performed analysis of articles. PB, SPS, GA, and MV contributed in manuscript preparation. GA and MV critically revised the manuscript. All authors read and approved the final manuscript. Funding Open access funding provided ...
- 1MB
- Puneet Bhatt, Sasidharan Pillai Sabeena, Muralidhar Varma, Govindakarnavar Arunkumar, Govindakarnava...
- 16
- 2021
this review we discuss the molecular mechanisms of dengue pathogenesis and highlight recent developments and gaps in our knowledge which are important for the identification of dengue biomarkers and drug targets.
Nov 19, 2023 · It was observed that PAIgG-coated platelets go through increased clearance via Fcγ receptors expressed on mononuclear phagocytic cells. The mechanism of action of IVIGs involves the ligation of inhibitory receptors or competitive suppression of Fcγ receptors.
People also ask
How does a dengue virus interact with the host cellular machinery?
Which proteins are involved in the pathogenesis of dengue virus?
What is the pathophysiology of dengue virus infection (DHF/DSS)?
Jan 15, 2023 · Human normally gets infected by dengue virus (DENV) through infected mosquitoes such as Aedes aegypti or Aedes albopictus (Bhatt et al., 2013). DENV will target on the dendritic cells (DCs) and macrophages during first day of infection (Kyle et al., 2007).
