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- The infected Langerhans cells display dengue viral antigens on their surface, which activates the innate immune response by alerting two types of white blood cells, called monocytes and macrophages, to fight the virus.
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Oct 10, 2018 · The innate immune response to DENV is not well characterized nor are the exact roles of the NS proteins in evading the immune response. The main innate immune response is type I IFN and the main evasion mechanism of the virus is to target against the type I IFN response.
- Innate Immune Response to Dengue Virus: Toll-like Receptors ...
During dengue infection, the host's innate immune response...
- Innate and adaptive immune evasion by dengue virus - PMC
The innate immune system acts as the first line of defense...
- Dengue virus and the host innate immune response - PubMed
Humans. Immunity, Innate* Substances. Antibodies, Viral....
- Innate Immune Response to Dengue Virus: Toll-like Receptors ...
The dengue virus also infects and replicates inside a specialized immune cell located in the skin, a type of dendritic cell called a Langerhans cell. What are Langerhans cells? Langerhans...
Jan 24, 2019 · Owing to the circulation of multiple serotypes, global expansion of the disease and recent gains in vaccination coverage, pre-existing immunity to dengue virus is abundant in the human...
- Ashley L St John, Ashley L St John, Abhay P S Rathore
- 2019
DENV passively escapes from innate immunity surveillance and also actively subverts the innate immune system at multiple steps. DENV targets both RNA-triggered RLR–mitochondrial antiviral signaling protein (RLR–MAVS) and DNA-triggered cGAS–STING signaling to reduce IFN production in infected cells.
