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  1. A drug overdose (overdose or OD) is the ingestion or application of a drug or other substance in quantities much greater than are recommended. Typically it is used for cases when a risk to health will potentially result. An overdose may result in a toxic state or death.

  2. over 110,000 (2017) An opioid overdose is toxicity due to excessive consumption of opioids, such as morphine, codeine, heroin, fentanyl, tramadol, and methadone. [3] [5] This preventable pathology can be fatal if it leads to respiratory depression, a lethal condition that can cause hypoxia from slow and shallow breathing. [3]

  3. Drug abuse, substance use disorder, substance misuse disorder: A 2007 assessment of harm from recreational drug use (mean physical harm and mean dependence liability) Specialty: Psychiatry: Complications: Drug overdose: Frequency: 27 million: Deaths: 1,106,000 US residents (1968–2020)

  4. Drug overdoses are one of the leading causes of injury death in adults and have risen over the past several decades in the United States (1–3). Overdoses involving synthetic opioids (fentanyl, for example) and stimulants (cocaine and methamphetamine, for example) have also risen in the past few years (1,4).

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  6. Data from the National Vital Statistics System. In 2021, 106,699 drug overdose deaths occurred, resulting in an age-adjusted rate of 32.4 per 100,000 standard population in the United States. Adults aged 65 and over had the largest percentage increase in rates from 2020 through 2021.

  7. The number of drug overdose deaths in 2020 was 91,799. Access data table for Figure 1 at: https://www.cdc.gov/nchs/data/databriefs/db428-tables.pdf1 . SOURCE: National Center for Health Statistics, National Vital Statistics System, Mortality. U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES.

  8. Key findings. Data from the National Vital Statistics System, Mortality. In 2018, there were 67,367 drug overdose deaths in the United States, a 4.1% decline from 2017 (70,237 deaths). The age-adjusted rate of drug overdose deaths in 2018 (20.7 per 100,000) was 4.6% lower than in 2017 (21.7).

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