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Flavivirus, renamed Orthoflavivirus in 2023, is a genus of positive-strand RNA viruses in the family Flaviviridae.The genus includes the West Nile virus, dengue virus, tick-borne encephalitis virus, yellow fever virus, Zika virus and several other viruses which may cause encephalitis, as well as insect-specific flaviviruses (ISFs) such as cell fusing agent virus (CFAV), Palm Creek virus (PCV ...
Jun 25, 2021 · Abstract. Flaviviruses are still a hidden threat to global human safety, as we are reminded by recent reports of dengue virus infections in Singapore and African-lineage-like Zika virus infections in Brazil. Therapeutic drugs or vaccines for flavivirus infections are in urgent need but are not well developed. The Flaviviridae family comprises a ...
- Rong Zhao, Meiyue Wang, Jing Cao, Jing Shen, Xin Zhou, Deping Wang, Jimin Cao
- 10.3390/life11070615
- 2021
- Life (Basel). 2021 Jul; 11(7): 615.
Nov 30, 2004 · The origin, evolution and spread of flaviviruses have been investi-gated by extensive genomic sequence analyses and calculating base substitution rates using sequences from the NS5, NS3 or E genes, or
- John S Mackenzie, Duane J Gubler, Lyle R Petersen
- 2004
Nov 22, 2021 · The first key step in the flavivirus life cycle is the attachment of viral glycoproteins to the host cell surface, followed by interaction with one or several host cell surface receptors. Flavivirus-host cell surface receptor interactions subsequently trigger virion internalisation by endocytosis . Even though attachment and entry are key steps ...
- Sophie Wilhelmina van Leur, Tiaan Heunis, Deeksha Munnur, Sumana Sanyal
- 10.1080/21505594.2021.1996059
- 2021
- Virulence. 2021; 12(1): 2814-2838.
The continued threat of flavivi-rus emergence and re-emergence highlights a need for a detailed fundamental understanding of the biology of these viruses, the immune responses that can contain ...
- Theodore C. Pierson, Michael S. Diamond
- 2020
May 4, 2020 · Abstract. Flaviviruses are vector-borne RNA viruses that can emerge unexpectedly in human populations and cause a spectrum of potentially severe diseases including hepatitis, vascular shock ...
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Feb 26, 2015 · To generate the most diverse phylogenetic dataset for the flaviviruses to date, we determined the genomic sequences and phylogenetic relationships of 14 flaviviruses, of which 10 are primarily associated with Culex spp. mosquitoes. We analyze these data, in conjunction with a comprehensive collection of flavivirus genomes, to characterize flavivirus evolutionary and biogeographic history in ...
