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  1. Nolan Ryan [1] [2] [3] has the most career strikeouts in Major League Baseball. During a record 27-year career, he struck out 5,714 batters. The American League record is held by Roger Clemens [4] (4,167 strikeouts), [5] while in the National League, the record is 4,000 by Steve Carlton. [6] [7]

  2. Reggie Jackson holds the record for the most career strikeouts by a batter with 2,597. Jim Thome [6] (2,548), Adam Dunn [7] (2,379), Sammy Sosa [8] (2,306), Alex Rodriguez [9] (2,287), Miguel Cabrera [10] (2,105), and Andrés Galarraga [11] (2,003) are the only other hitters to strike out over 2,000 times.

  3. Career SO Leaders:1.Nolan Ryan+/5714/957, 2.Randy Johnson+/4875/691, 3.Roger Clemens/4672/213, 4.Steve Carlton+/4136/1881, 5.Bert Blyleven+/3701/514, 6.Tom Seaver+/3640/1552, 7.Don Sutton+/3574/1559, 8.Gaylord Perry+/3534/1220, 9.Walter Johnson+/3509/2534, 10. Justi

    Rank
    Player (yrs, Age)
    Strikeouts
    Ip
    1.
    Nolan Ryan+ (27)
    5714
    5386.0
    2.
    Randy Johnson+ (22)
    4875
    4135.1
    3.
    Roger Clemens (24)
    4672
    4916.2
    4.
    Steve Carlton+ (24)
    4136
    5217.2
  4. Nolan Ryan has 5,714 career strikeouts, the most in Major League history. His 11 seasons as a strikeout leader – second only to the 12 of Walter Johnson – includes nine seasons, between 1972 and 1990, as the American League strikeout leader. Three-time strikeout champion Johan Santana won the American League's last pitching triple crown in ...

  5. Career SO Leaders:1.Reggie Jackson+/2597/11418, 2.Jim Thome+/2548/10313, 3.Adam Dunn/2379/8328, 4.Sammy Sosa/2306/9896, 5.Alex Rodriguez/2287/12207, 6.Miguel Cabrera/2105/11796, 7.Andrés Galarraga/2003/8916, 8.Justin Upton/1971/7649, 9.José Canseco/1942/8129, 10.Willie&nbs

  6. Record Player # Most wins Cy Young: 511 Most losses Cy Young 316 Most no-hitters Nolan Ryan: 7 Most strikeouts Nolan Ryan 5,714 Most shutouts Walter Johnson: 110 Most pickoffs Steve Carlton: 144 Most innings pitched Cy Young 7,354 + 2 ⁄ 3: Most hit batsmen Gus Weyhing: 278 Most home runs allowed Jamie Moyer: 522 Most complete games Cy Young 749

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  8. May 21, 2024 · References. Nolan Ryan [1] [2] [3] has the most career strikeouts in Major League Baseball. During a record 27-year career, he struck out 5,714 batters. The American League record is held by Roger Clemens [4] (4,167 strikeouts), [5] while in the National League, the record is 4,000 by Steve Carlton. [6] [7]