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Endocytosis
- The dengue virus attaches to the surface of a host cell and enters the cell by a process called endocytosis. Once deep inside the cell, the virus fuses with the endosomal membrane and is released into the cytoplasm. The virus particle comes apart, releasing the viral genome.
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Oct 25, 2010 · To infect a cell, the dengue virus initially binds to the cell surface. It gains entry into the cell when it becomes enveloped by the cell membrane during the creation of a pouch-like structure known as an endosome.
Jun 13, 2019 · The virus enters the mosquito’s system via viremic blood and infects the midgut epithelial cells. It replicates in the midgut cells and then gets released into the hemocoel and disseminates to other tissues via hemolymph, ultimately reaching the salivary glands to infect fresh hosts in subsequent bites.
- Debica Mukherjee, Sandeepan Das, Feroza Begum, Sweety Mal, Upasana Ray
- 10.3390/pathogens8020077
- 2019
- Pathogens. 2019 Jun; 8(2): 77.
The dengue virus attaches to the surface of a host cell and enters the cell by a process called endocytosis. Once deep inside the cell, the virus fuses with the endosomal...
Dec 15, 2021 · DENV infection inductees after the attachment of the dengue virus to the target cell through interfaces between the various cell surface receptors and viral envelope (E) protein . In mammalian cells, all categorized serotypes interact with mannose, heparan sulfate, nLc4Cer, and DC-SIGN/L-SIGN receptors.
- 10.1155/2021/4224816
- 2021
- Biomed Res Int. 2021; 2021: 4224816.
We describe in detail the putative receptors and attachment factors in mammalian and mosquito cells, and the recognition of viral immunocomplexes via Fcγ receptor in immune cells. We also discuss that virus internalization might occur through distinct entry pathways, including clathrin-mediated or non-classical clathrin-independent endocytosis ...
The researchers discovered how the dengue virus releases itself from the protective membrane that shields it as it penetrates deep inside the cell. The discovery allows researchers to study the invasion process in the laboratory and provides a means to test potential treatments for the virus.
