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     • Dengue fever is caused by one of four dengue viruses. When a mosquito infected with the dengue virus bites you, the virus can enter your blood and make copies of itself. The virus itself and your immune system’s response can make you feel sick. The virus can destroy parts of your blood that form clots and give structure to your blood vessels.
     my.clevelandclinic.org › health › diseases

     Dengue Fever: Causes, Symptoms & Treatment - Cleveland Clinic

2. People also ask

   How does the dengue virus affect white blood cells?

   • Normally, monocytes and macrophages ingest and destroy pathogens, but instead of destroying the dengue virus, both types of white blood cells are targeted and infected by the virus. The dengue virus tricks the immune system to get around its defenses and infect more cells.

   Host Response to the Dengue Virus | Learn Science at Scitable - Nature

   www.nature.com/scitable/topicpage/host-response-to-the-dengue-virus-22402106/

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   How does the dengue virus get into a cell?

   • Each year, the virus infects up to 100 million people and kills about 22,000, most of them children. To infect a cell, the dengue virus initially binds to the cell surface. It gains entry into the cell when it becomes enveloped by the cell membrane during the creation of a pouch-like structure known as an endosome.

   How Dengue Virus Infects Cells - National Institutes of Health (NIH)

   www.nih.gov/news-events/nih-research-matters/how-dengue-virus-infects-cells

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   What causes severe manifestations of dengue virus disease?

   • The exact mechanisms responsible for severe manifestations of dengue virus disease are not yet fully elucidated and are likely to be multifactorial. DENV infection can have diverse presentations in different hosts, which cannot be explained by a single hypothesis alone.

   Current Understanding of the Pathogenesis of Dengue Virus Infection

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7815537/

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3. www.ncbi.nlm.nih.gov › pmc › articlesCurrent Understanding of the Pathogenesis of Dengue Virus...

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 24, 2020 · The pathogenesis of dengue virus infection and severe dengue manifestations is very complex and not completely understood. The pathophysiological hallmark of DHF/DSS is plasma leakage and deranged hemostasis.

   • Fig. 1

     The pathogenesis of dengue virus infection is attributed to...

   • How Dengue Virus Infects Cells

     Without treatment, the virus can cause damage to blood and...

4. www.ncbi.nlm.nih.gov › pmc › articlesThe Mosquito Immune System and the Life of Dengue Virus: What ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Jun 13, 2019 · Organ-specific mosquito antiviral strategies. (A): In the Ae. aegypti system, DENV enters through blood meal and replicates inside the mid-gut. From the mid-gut, DENV is released to the hemolymph, salivary glands, and brain.

   • Author: Debica Mukherjee, Sandeepan Das, Feroza Begum, Sweety Mal, Upasana Ray
   • DOI: 10.3390/pathogens8020077

   • Publish Year: 2019
   • Publication: Pathogens. 2019 Jun; 8(2): 77.

5. www.nature.com › scitable › topicpageHost Response to the Dengue Virus | Learn Science at Scitable

   www.nature.com › scitable › topicpage

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   During its journey, the dengue virus infects more cells, including those in the lymph nodes and bone marrow, macrophages in both the spleen and liver, and monocytes in the blood.

6. www.ncbi.nlm.nih.gov › pmc › articlesIs dengue a threat to the blood supply? - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Oct 2, 2008 · The principal mechanisms by which dengue virus infection causes DHF are still not clearly elucidated and are believed to be a result of viral and host factors that involve the activation of T cells, production of cytokines/chemokines and disturbance of the haemostatic system.

   • Author: D. Teo, L. C. Ng, S. Lam
   • DOI: 10.1111/j.1365-3148.2009.00916.x

   • Publish Year: 2009
   • Publication: Transfus Med. 2009 Apr; 19(2): 66-77.

7. www.nature.com › scitable › contentImmune response to dengue infection | Learn Science at Scitable

   www.nature.com › scitable › content

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   As the immune response fights the dengue infection, the person’s B cells begin producing IgM and IgG antibodies that are released in the blood and lymph fluid, where they recognize and...

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9. my.clevelandclinic.org › health › diseasesDengue Fever: Causes, Symptoms & Treatment - Cleveland Clinic

   my.clevelandclinic.org › health › diseases

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   Jun 6, 2022 · Dengue fever is caused by one of four dengue viruses. When a mosquito infected with the dengue virus bites you, the virus can enter your blood and make copies of itself. The virus itself and your immune system’s response can make you feel sick. The virus can destroy parts of your blood that form clots and give structure to your blood vessels.