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     • These criteria, which are described in the Preamble to the IARC Monographs (Cogliano et al., 2004; IARC, 2006), are used to evaluate and integrate the evidence provided by human epidemiological studies, animal cancer bioassays, and information on possible biological mechanisms of action, to classify agents into one of the following categories: carcinogenic to humans (Group 1), probably carcinogenic to humans (Group 2A), possibly carcinogenic to humans (Group 2B), not classifiable as to its...
     www.ncbi.nlm.nih.gov › books › NBK570329

     Analysis of key characteristics of human carcinogens

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   What are IARC assessments of carcinogenicity based on?

   • IARC assessments of carcinogenicity are based on, and necessarily limited to, scientific evidence available at the time of the review. The evidence comes from epidemiologic studies, animal bioassays, pharmacokinetic/mechanistic experiments, and surveys of human exposure.

   IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Hum…

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   How does the IARC select a carcinogenic agent?

   • The IARC staff makes the final selection of agents for review by taking into account the prevalence and intensity of exposure (of both occupational groups and the general population) and availability of sufficient literature for an evaluation of carcinogenicity, as well as advice from the Advisory Groups.

   IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Hum…

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4455595/

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   What are the different levels of evidence for carcinogenicity?

   • There are two subcategories, which indicate different levels of evidence. This category is used when there is limited evidence of carcinogenicity in humans and either sufficient evidence of carcinogenicity in experimental animals or strong mechanistic evidence, showing that the agent exhibits key characteristics of human carcinogens.

   Questions and Answers - monographs.iarc.who.int

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   Do IARC Working Groups review evidence of carcinogenicity?

   • Although IARC working groups have always conducted comprehensive reviews of evidence of carcinogenicity, advances in systematic review methods ( 10–15) provide a basis for more specific guidance to working group members, thereby enhancing consistency and transparency.

   The IARC Monographs: Updated Procedures for Modern and Transparent

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3. www.ncbi.nlm.nih.gov › pmc › articlesIARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to...

   www.ncbi.nlm.nih.gov › pmc › articles

   Feb 24, 2015 · The terms probably carcinogenic and possibly carcinogenic have no quantitative significance and are used simply as descriptors of different levels of evidence of human carcinogenicity, with probably carcinogenic signifying a higher level of evidence than possibly carcinogenic.

   • The IARC Monographs: Updated Procedures for Modern and ...

     Through this synthetic review process, the working group...

   • Analysis of key characteristics of human carcinogens

     Since its establishment in the early 1970s, the IARC...

4. www.iarc.who.int › iarc-monographs-classificationIARC Monographs hazard classification – IARC

   www.iarc.who.int › iarc-monographs-classification

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   Jun 16, 2023 · This infographic presents the categories used by the IARC Monographs on the Identification of Carcinogenic Hazards to Humans to classify a substance according to the level of certainty that the substance can cause cancer.

5. monographs.iarc.who.int › wp-content › uploadsIARC Monographs on the Identification of Carcinogenic Hazards ...

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   Agents can also be classified in Group 1 on the basis of sufficient evidence of carcinogenicity in experimental animals supported by strong evidence in exposed humans that the agent exhibits one or more of the recognized key characteristics of human carcinogens.

6. canceratlas.cancer.org › human-carcinogensHuman Carcinogens | The Cancer Atlas

   canceratlas.cancer.org › human-carcinogens

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   Sometimes called the WHO “Encyclopedia of Carcinogens,” the IARC Monographs are critical reviews and evaluations of the weight of the evidence that an agent can increase the risk of cancer in humans.

7. monographs.iarc.who.int › agents-classified-by-theAgents Classified by the IARC Monographs , Volumes 1–135

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   Dec 1, 2023 · Note: In September 2022, four additional individual Group 1 agents were created by splitting up some existing agent groupings because not all agents in the groups had the same cancer sites with sufficient and limited evidence for cancer in humans. Three strains of human papillomavirus (HPV) were split from a larger grouping of HPV strains.