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10,700 bases
- It is a single-stranded positive-sense ribonucleic acid virus with 10,700 bases.
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Sep 20, 2019 · In the case of DENV-1 the 3′ UTR is ~470 nucleotides long, 450 nucleotides for DENV-2, 430 nucleotides for DENV-3, and the shortest is for DENV-4 with 385 nucleotides 3′ UTR can be divided in three domains (Proutski et al., 1997, Rauscher et al., 1997). Domain I is located immediately after the stop codon of NS5 and is considered the most ...
- Clinical Manifestations and Management of Dengue/DHF/DSS
Clinical course of DHF. DHF clinical course (Figure 2) is...
- Figure 16.7
Dengue virus (DENV) belongs to the family Flaviviridae,...
- A Case Control Study
Table S3: Descriptive analysis of demographics and...
- What If
1993 Mar 19; 259 (5102):1745–1749. [Google Scholar]...
- 5-Year Multi-Center Retrospective Study
The lowest estimated incidence of adult dengue death was 6.8...
- Clinical Features of Dengue in a Large Vietnamese Cohort
Notably, age also significantly affected the platelet count...
- Dengue Emergence and Adaptation to Peridomestic Mosquitoes
Dengue is caused by any of four antigenically distinct...
- An Escalating Public Health Problem in Latin America
The Re-Emergence of Dengue in Latin America. Following the...
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May 17, 2021 · With our predictive approach, we achieved high prediction scores of the secondary structure (AUC up to 0.85 with experimental data), and computed consensus secondary structure profiles using hundreds of in silico models.
- Riccardo Delli Ponti, Marek Mutwil
- 10.1186/s12864-021-07638-7
- 2021
- BMC Genomics. 2021; 22: 352.
- Structural Properties of The Denv Genomes
- Comparison of Structural Properties of The VHF Genomes
- Structural Content Can Be Used to Classify Vhfs
- Geographical Distribution of Denv Serotypes
Here, we analysed the secondary structure profiles of the complete genomes of more than 7000 ss-RNA viruses (Table 1; Methods: Source of viral genomes). The structural profiles were generated using the CROSS algorithm, a fast and comprehensive alternative to profile the structural content (i.e., % of double-stranded nucleotides) of long and complex...
Interestingly, DENV serotypes tend to be less structured than other flaviviruses, such as West Nile Fever virus (WNV), Yellow Fever virus (YFV), Tick-borne Encephalitis virus (TBV), and Japanese Encephalitis virus (JEV; Fig. 2). Even if not properly a VHF, we also used as comparison Zika virus (ZIKV), due to the similarities with DENV not only in t...
The overall similarities and differences in structure are an additional feature that could be employed to characterise the different viruses. For the next step, the structural content (mean of the % of double-stranded nucleotides for all the viral genomes) in a specific species was used to hierarchically group the 11 different viruses (Methods: Hie...
We also studied the geographical connection between DENV serotypes and the secondary structure content. We found that the African DENV-1 is predicted to be more structured than the other serotypes, even when compared with the Asian strains (Supplementary Figure 5 Kolmogorov-Smirnov = 0.001), while on the contrary, Asian DENV-3 is more structured th...
- Riccardo Delli Ponti, Marek Mutwil
- 2021
Oct 23, 2020 · We introduce an assay to amplify near full-length dengue virus genomes as intact molecules, sequence these amplicons with third generation “nanopore” technology without fragmenting and use the...
- Thiruni N Adikari, Thiruni N Adikari, Nasir Riaz, Nasir Riaz, Chathurani Sigera, Preston Leung, Brau...
- 2020
Jan 10, 2017 · DENV contains 10 723 nucleotides in a single-strand positive RNA genome, which encodes a large polyprotein precursor of 3391 amino-acid residues. The polyprotein of DENV comprises three structural proteins (C, prM and E) and seven nonstructural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5) [ 15–19 ].
- Vivek Dhar Dwivedi, Indra Prasad Tripathi, Ramesh Chandra Tripathi, Shiv Kumar Bharadwaj, Sarad Kuma...
- 2017
Aug 30, 2013 · Nucleoside analogues are usually prodrugs that need to be converted to their antiviral nucleotide metabolite forms. Ribavirin (1-β-d-ribofuranosyl-1 H -1, 2, 4-triazole-3-carboxamide) possesses broad spectrum antiviral activity and is used in combination with IFN to combat HCV infection.
The Viral Genomes Resource is a collection of viral genomic sequences that is a part of the Entrez Genomes, which provides curated sequence data and annotations of complete genomes to the scientific community.
