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10 723 nucleotides
- DENV contains 10 723 nucleotides in a single-strand positive RNA genome, which encodes a large polyprotein precursor of 3391 amino-acid residues.
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Nov 24, 2020 · Dengue virus genome encodes for three structural proteins (C, prM (M), and E) and seven non-structural (NS) proteins (NS1, NS2a, NS2B, NS3, NS4a, NS4B, and NS5). The most important non-structural protein which has been implicated in the pathogenesis of dengue viral infections is NS1 [ 23 ].
Dengue virus is an arbovirus belonging to class Flaviviridae Its clinical manifestation ranges from asymptomatic to extreme conditions (dengue hemorrhagic fever/dengue shock syndrome). A lot of research has been done on this ailment, yet there is no effective treatment available for the disease.
- Sitara Nasar, Naeem Rashid, Saima Iftikhar
- 2020
Sep 20, 2019 · These DENV can cause a spectrum of illness ranging from asymptomatic dengue infection to dengue fever (DF) to dengue hemorrhagic fever (DHF) to dengue shock syndrome (DSS). It is estimated that close to 3.6 billion are at risk with 390 million infections of which 96 million are symptomatic.
- Amudhan Murugesan, Mythreyee Manoharan
- 2020
- 10.1016/B978-0-12-819400-3.00016-8
Sep 3, 2021 · It has four antigenically distinct serotypes, DENV-1 to DENV-4, with different genotypes and three structural proteins and seven non-structural proteins. Clinical symptoms of dengue range from mild fever to severe dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS), with thrombocytopenia, leucopenia, and increased vascular permeability.
- Sudipta Kumar Roy, Soumen Bhattacharjee
- 2021
Sep 30, 2021 · As the name suggests, structural proteins—Capsid (C), Envelope (E), pre-Membrane (prM)—are the structural component of a virus particle, involved in the encapsidation of viral RNA, i.e., nucleocapsid formation, membrane formation, maturation, and envelopment of the virion.
- Nikita Nanaware, Anwesha Banerjee, Satarupa Mullick Bagchi, Parikshit Bagchi, Anupam Mukherjee
- 10.3390/v13101967
- 2021
- Viruses. 2021 Oct; 13(10): 1967.
Feb 17, 2022 · The viral genome encodes one polyprotein that can be processed into three structural proteins—capsid protein (C), membrane protein (M) and envelope protein (E)—and seven nonstructural proteins—NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5 ( Figure 1) [ 20 ].
Jan 10, 2017 · Both types of dengue fever, dengue hemorrhagic fever [ 1–8] and dengue shock syndrome, are deadly infections of five different serotypes of this virus (DENV 1–5) [ 9–14 ]. DENV contains 10 723 nucleotides in a single-strand positive RNA genome, which encodes a large polyprotein precursor of 3391 amino-acid residues.
