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10,700 bases
- It is a single-stranded positive-sense ribonucleic acid virus with 10,700 bases.
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Sep 20, 2019 · In the case of DENV-1 the 3′ UTR is ~470 nucleotides long, 450 nucleotides for DENV-2, 430 nucleotides for DENV-3, and the shortest is for DENV-4 with 385 nucleotides 3′ UTR can be divided in three domains (Proutski et al., 1997, Rauscher et al., 1997). Domain I is located immediately after the stop codon of NS5 and is considered the most ...
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May 17, 2021 · Dengue 1 virus: DENV-1: Flavivirus: Yes a (severe) 1634: 10,500: Dengue 2 virus: DENV-2: Flavivirus: Yes a (severe) 1184: 9750: Dengue 3 virus: DENV-3: Flavivirus: Yes a (severe) 772: 10,590: Dengue 4 virus: DENV-4: Flavivirus: Yes a (severe) 176: 9730: Zika virus: ZIKV: Flavivirus: No: 258: 10,120: Chikungunya virus: CHIKV: Togavirus: Yes a ...
- Riccardo Delli Ponti, Marek Mutwil
- 10.1186/s12864-021-07638-7
- 2021
- BMC Genomics. 2021; 22: 352.
- Structural Properties of The Denv Genomes
- Comparison of Structural Properties of The VHF Genomes
- Structural Content Can Be Used to Classify Vhfs
- Geographical Distribution of Denv Serotypes
Here, we analysed the secondary structure profiles of the complete genomes of more than 7000 ss-RNA viruses (Table 1; Methods: Source of viral genomes). The structural profiles were generated using the CROSS algorithm, a fast and comprehensive alternative to profile the structural content (i.e., % of double-stranded nucleotides) of long and complex...
Interestingly, DENV serotypes tend to be less structured than other flaviviruses, such as West Nile Fever virus (WNV), Yellow Fever virus (YFV), Tick-borne Encephalitis virus (TBV), and Japanese Encephalitis virus (JEV; Fig. 2). Even if not properly a VHF, we also used as comparison Zika virus (ZIKV), due to the similarities with DENV not only in t...
The overall similarities and differences in structure are an additional feature that could be employed to characterise the different viruses. For the next step, the structural content (mean of the % of double-stranded nucleotides for all the viral genomes) in a specific species was used to hierarchically group the 11 different viruses (Methods: Hie...
We also studied the geographical connection between DENV serotypes and the secondary structure content. We found that the African DENV-1 is predicted to be more structured than the other serotypes, even when compared with the Asian strains (Supplementary Figure 5 Kolmogorov-Smirnov = 0.001), while on the contrary, Asian DENV-3 is more structured th...
- Riccardo Delli Ponti, Marek Mutwil
- 2021
The structure of the dengue virus is roughly spherical, with a diameter of approximately 50 nm (1 nm is one millionth of 1 mm) (Figure 3). The core of the virus is the nucleocapsid, a structure ...
Oct 23, 2020 · Dengue is a major public health problem with nearly half the global population at risk of infection 1,2.The incidence of dengue has increased by more than 30-fold in the last 50 years, and the ...
- Thiruni N Adikari, Thiruni N Adikari, Nasir Riaz, Nasir Riaz, Chathurani Sigera, Preston Leung, Brau...
- 2020
Aug 30, 2013 · Dengue viruses (DENVs) cause the most common arthropod-borne viral disease in man with 50–100 million infections per year. Because of the lack of a vaccine and antiviral drugs, the sole measure of control is limiting the Aedes mosquito vectors. DENV infection can be asymptomatic or a self-limited, acute febrile disease ranging in severity.
Jun 11, 2015 · Within each of the four DENV serotypes, which share ~65–70 % amino acid sequence similarity [ 20 ], virus strains are further classified into distinct genotypes, which can vary by ~6–8 % at the nucleotide level and by 3 % at the amino acid level [ 21 – 24 ].
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