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  2. Huntington's disease (HD), also known as Huntington's chorea, is an incurable neurodegenerative disease that is mostly inherited. The earliest symptoms are often subtle problems with mood or mental/psychiatric abilities. A general lack of coordination and an unsteady gait often follow.

    • Gait

      Humans using a running gait. The runner in the back and on...

    • Huntingtin Gene

      Huntingtin (Htt) is the protein coded for in humans by the...

    • Overview
    • Symptoms
    • Causes
    • Risk Factors
    • Complications
    • Prevention

    Huntington's disease causes nerve cells in the brain to decay over time. The disease affects a person's movements, thinking ability and mental health. Huntington's disease is rare. It's often passed down through a changed gene from a parent. Huntington's disease symptoms can develop at any time, but they often begin when people are in their 30s or ...

    Huntington's disease usually causes movement disorders. It also causes mental health conditions and trouble with thinking and planning. These conditions can cause a wide spectrum of symptoms. The first symptoms vary greatly from person to person. Some symptoms appear to be worse or have a greater effect on functional ability. These symptoms may cha...

    Huntington's disease is caused by a difference in a single gene that's passed down from a parent. Huntington's disease follows an autosomal dominant inheritance pattern. This means that a person needs only one copy of the nontypical gene to develop the disorder. With the exception of genes on the sex chromosomes, a person inherits two copies of eve...

    People who have a parent with Huntington's disease are at risk of having the disease themselves. Children of a parent with Huntington's have a 50 percent chance of having the gene change that causes Huntington's.

    After Huntington's disease starts, a person's ability to function gradually gets worse over time. How quickly the disease gets worse and how long it takes varies. The time from the first symptoms to death is often about 10 to 30 years. Juvenile Huntington's disease usually results in death within 10 to 15 years after symptoms develop. The depressio...

    People with a known family history of Huntington's disease may be concerned about whether they may pass the Huntington gene on to their children. They might consider genetic testing and family planning options. If an at-risk parent is considering genetic testing, it can be helpful to meet with a genetic counselor. A genetic counselor explains the p...

  3. Sep 27, 2023 · What is Huntington’s disease chorea? One of the first physical symptoms of Huntington’s disease is chorea. Chorea is unintended jerks or twisting movements. Chorea usually affects your hands, fingers and facial muscles first. Later, it also makes your arms, legs and torso move uncontrollably.

  4. Dec 4, 2023 · People living with HD develop uncontrollable dance-like movements (chorea) and abnormal body postures, as well as problems with behavior, emotion, thinking, and personality. For example, uncontrolled movements in the person's fingers, feet, face, or torso. These movements are signs of chorea.

  5. George Huntington George Huntington (April 9, 1850 – March 3, 1916) was an American physician from Long Island, New York who contributed the clinical description of the disease that bears his name — Huntington's disease. Dr. Huntington wrote his paper “On Chorea” when he was 22 years old, a year after receiving his medical degree.

  6. en.wikipedia.org › wiki › HyperkinesiaHyperkinesia - Wikipedia

    Huntington's disease. Hyperkinesia, more specifically chorea, is the hallmark symptom of Huntington's disease, formerly referred to as Huntington's chorea. Appropriately, chorea is derived from the Greek word, khoros, meaning "dance." The extent of the hyperkinesia exhibited in the disease can vary from solely the little finger to the entire ...

  7. Huntington's disease is a genetic disorder caused by mutation in a gene located on chromosome 4. It affects the brain and gets worse over time. This can lead to problems with moving, memory loss as well as thinking skills. Lastly, it also causes changes in behavior. Chorea is one of the main symptoms of Huntington's disease.

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