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Design: Prospective study. Setting: ICU. Patients: Fifty-one patients with an acute circulatory failure (78% of septic origin). Measurements: Before and after a volume expansion (500 mL of saline), we measured cardiac index, o2- and Co2-derived variables and lactate.
- Xavier Monnet, Florence Julien, Nora Ait-Hamou, Marie Lequoy, Clément Gosset, Mathieu Jozwiak, Romai...
- 2013
Aug 31, 2021 · In this chapter, we present the physiological and pathophysiological determinants of the Pv-aCO 2 gap and review its implications in the clinical assessment of circulatory shock. Go to: Physiological aspects of CO 2 production and transport.
- Zied Ltaief, Antoine Guillaume Schneider, Lucas Liaudet
- 10.1186/s13054-021-03671-w
- 2021
- Crit Care. 2021; 25: 318.
- Design and Setting
- Inclusion and Exclusion Criteria
- Data and Sample Collections
- Definitions and Outcome
- Statistical Analysis
This is prospective observational study enrolled patients treated in the 33-bed Intensive Care Unit (ICU) of Brugmann Hospital in Brussels, Belgium. The patients received FB between January and June 2015. Approval was obtained from the local Ethics Committee (CE2014/122), and written informed consent was obtained by the patient’s next of kin accord...
Critically ill adult patients (> 18 years of age) with blood-lactate levels > 1.5 mmol/L who received FBs in less than 50 min were considered eligible for the study . The exclusion criteria were: 1) a lack of jugular or subclavian venous catheter and arterial catheter; 2) FB using Ringer’s lactate solutions, to avoid any increasing of blood lactate...
Demographics, the type of fluids used for FB, concomitant treatments (mechanical ventilation, inotropic agents), and laboratory data were collected for each patient. The Acute Physiology and Chronic Health Evaluation (APACHE) II score upon admission was used to assess disease severity. Before and after FB, we measured the cardiac index (CI) using D...
Sepsis and septic shock were defined according to Sepsis-3 definition . Enhanced oxygen extraction was defined as OER > 40% and/or ScvO2 < 60%. A significant decrease in lactate concentrations was defined as: a) post-FB lactate < 1.5 mmol/L) or b) a decrease of more than 10% from baseline values . High PvaCO2/CavO2 was defined as a value ≥ 1.4 . A ...
Statistical analyses were done in R through the R-studio interface (www.r-project.org, R version 3.3.1). Descriptive statistics were computed for all study variables. A Kolmogorov–Smirnov test was used, and histograms and normal-quantile plots were examined to verify the normality of the distribution of continuous variables. Absolute changes (Δ = A...
Compared with the volume-responders in whom oxygen consumption did not increase, the volume-responders in whom oxygen consumption increased ≥15% were characterized by a higher lactate (2.3 ± 1.1 mmol/L vs. 5.5 ± 4.0 mmol/L, respectively) and a higher ratio of the veno-arterial carbon dioxide tension difference (P(v − a)Co 2) over the ...
Dec 1, 2015 · Monnet X, Julien F, Ait-Hamou N, Lequoy M, Gosset C, Jozwiak M, et al. Lactate and venoarterial carbon dioxide difference/arterial-venous oxygen difference ratio, but not central venous oxygen saturation, predict increase in oxygen consumption in fluid responders.
- Jaume Mesquida, Paula Saludes, Guillem Gruartmoner, Cristina Espinal, Eva Torrents, Francisco Baigor...
- 2015
Apr 8, 2015 · According to the Fick equation, V CO 2 equals the product of cardiac output by the difference between mixed venous and arterial CO 2 contents (C mv–a CO 2) whereas V O 2 equals the product of cardiac output by the difference between arterial and mixed venous O 2 contents (C a–mv O 2) (Fig. 1 ).
Jun 1, 2013 · Lactate and Venoarterial Carbon Dioxide Difference/Arterial-Venous Oxygen Difference Ratio, but Not Central Venous Oxygen Saturation, Predict Increase in Oxygen Consumption in Fluid Responders*. X. Monnet, Florence Julien, +7 authors. J. Teboul.
