Search results
People also ask
Which NMDA receptor is responsible for ketamine's more specific properties?
Is ketamine a non-competitive channel blocker of NMDA receptors?
What are the subanesthetic effects of the noncompetitive NMDA antagonist ketamine?
NMDA receptor antagonists induce a state called dissociative anesthesia, marked by catalepsy, amnesia, and analgesia. Ketamine is a favored anesthetic for emergency patients with unknown medical history and in the treatment of burn victims because it depresses breathing and circulation less than other anesthetics.
Nov 2, 2016 · There is increasing scientific and clinical interest in understanding mechanisms underlying the psychiatric effects of ketamine and other N-methyl-d-aspartate receptor (NMDAR) antagonists.
- Charles F. Zorumski, Yukitoshi Izumi, Steven Mennerick
- 2016
Jul 28, 2021 · These findings show structurally how ketamine binds to and acts on human NMDA receptors, and pave the way for the future development of ketamine-based antidepressants.
- Youyi Zhang, Fei Ye, Tongtong Zhang, Shiyun Lv, Liping Zhou, Daohai Du, He Lin, Fei Guo, Cheng Luo, ...
- 2021
Jan 30, 2024 · Ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) and glutamate receptor antagonist that blocks HCN1 receptors. The unique dissociative action and partial agonism of opiate mu-receptors permit painful procedures in a consistent state of sedation and comfort.
- 2024/01/30
4 days ago · The core advance of the study involved biophysically modeling what happens when ketamine blocks the “NMDA” receptors in the brain’s cortex — the outer layer where key functions such as sensory processing and cognition take place. Blocking the NMDA receptors modulates the release of excitatory neurotransmitter glutamate.
Apr 10, 2013 · Ketamine essentially acts on glutamate binding sites, NMDA (N‐Methyl‐D‐Aspartate), and non‐NMDA receptors 70. The antagonism of NMDA receptor is responsible for the specific ketamine properties (amnesic and psychosensory effects, analgesia, and neuroprotection).
Apr 4, 2024 · Many research endeavors have sought to identify ketamine’s mechanism of action in mood disorders; while many studies have focused on ketamine’s role in glutamatergic modulation, several studies...
