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Low-molecular-weight heparin (LMWH) is a class of anticoagulant medications. They are used in the prevention of blood clots and, in the treatment of venous thromboembolism (deep vein thrombosis and pulmonary embolism), and the treatment of myocardial infarction.
Heparin – Wikipedia tiếng Việt. Nội dung. ẩn. Đầu. Chú thích. Heparin, còn được gọi là heparin không phân đoạn (UFH), là một loại thuốc được sử dụng với vai trò là chất chống đông máu (chất làm loãng máu). [3] . Cụ thể hơn thì thuốc này được sử dụng để điều trị và ngăn chặn huyết khối tĩnh mạch sâu, thuyên tắc phổi, và huyết khối động mạch. [3] .
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Aug 4, 2023 · Identify the mechanism of action of various low molecular weight heparin agents. Summarize the indications for using LMWH agents. Review the adverse event profiles of various LMWH agents, summarizing the key differences.
- Francesca Solari, Matthew Varacallo
- 2023/08/04
- 2019
A fractionated version of heparin, known as low molecular weight heparin, is also available. [14] History. Heparin was discovered by Jay McLean and William Henry Howell in 1916, although it did not enter clinical trials until 1935. [15] .
Defined as heparin salts having an average molecular weight of less than 8000 Dalton; LMWHs inhibit the coagulation process through binding to antithrombin which in turn inhibits activated factor X. LMWH therapy is monitored by the anti-factor Xa assay (measures anti-factor Xa activity).
Low-molecular-weight hep-arins are fragments of unfractionated heparin pro-duced by controlled enzymatic or chemical depoly-merization processes that yield chains with a mean molecular weight of about 5000 (Table 1).
Low molecular weight heparin (LMWH) is produced through a controlled depolymerization of unfractionated heparin. LMWH exhibits a higher anti-Xa/anti-IIa activity ratio and is useful as it does not require monitoring of the APTT coagulation parameter and has fewer side effects.
