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Roxithromycin. Macrolides are a class of mostly natural products with a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The lactone rings are usually 14-, 15-, or 16-membered. Macrolides belong to the polyketide class of natural products. Some macrolides have antibiotic or ...
macrolide, class of antibiotics characterized by their large lactone ring structures and by their growth-inhibiting (bacteriostatic) effects on bacteria. The macrolides were first discovered in the 1950s, when scientists isolated erythromycin from the soil bacterium Streptomyces erythraeus .
- The Editors of Encyclopaedia Britannica
In addition to erythromycin, macrolides now available in the United States include azithromycin and clarithromycin. These two new macrolides are more chemically stable and better tolerated than erythromycin, and they have a broader antimicrobial spectrum than erythromycin against Mycobacterium avium complex (MAC), Haemophilus influenzae, nontuberculous mycobacteria, and Chlamydia trachomatis.
- Salvador Alvarez-Elcoro, Mark J. Enzler
- 1999
Feb 1, 2020 · Go to: Indications. Macrolides are naturally occurring compounds comprised of a lactone ring with deoxy sugars attached. Certain macrolides have antibiotic or antifungal properties and are used in pharmaceutical antimicrobial therapy.
- Parth H. Patel, Muhammad F. Hashmi
- 2023/05/16
- LECOM, National Health Service
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Macrolides are antibiotics that are primarily bacteriostatic; by binding to the 50S subunit of the ribosome, they inhibit bacterial protein synthesis. Mechanisms of Action: Protein Synthesis Inhibitors. Image. Copyright © 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates. All rights reserved.
Macrolides are a class of antibiotics derived from Saccharopolyspora erythraea (originally called Streptomyces erythreus ), a type of soil-borne bacteria. Macrolides inhibit protein synthesis in bacteria by reversibly binding to the P site of the 50S unit of the ribosome. Macrolides mainly affect gram-positive cocci and intracellular pathogens ...
Aug 10, 2017 · Macrolide antibiotics are classified according to the size of the macrocyclic lactone ring as being either 12‐, 14‐, 15‐ or 16‐membered ring macrolides (Figure 1 ). The majority of macrolides contain amino sugar and/or neutral sugar moieties connected to the lactone ring via a glycosylic bond. Figure 1. Macrolide structures.
