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Promoting blood flow
- Nitroglycerin is a medication that treats angina and anal fissures. It works by promoting blood flow. The body breaks nitroglycerin down into nitric oxide. Nitric oxide causes the smooth muscle within the blood vessels to relax. This allows the arteries and veins to open up, allowing more blood to flow through.
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Nitroglycerin causes the relaxation of vascular smooth muscles, causing arteriolar and venous dilatation. 17 It increases blood flow to the myocardium and reduces cardiac preload and afterload, decreasing myocardial wall stress and ameliorating anginal symptoms. 3,10,12 Nitroglycerin also reduces coronary artery spasm, decreasing systemic ...
Jul 31, 2023 · Summarize the mechanism of action of nitroglycerin. Outline nitroglycerin's adverse event profile. Describe interprofessional team strategies for improving care coordination and communication to properly use nitroglycerin to improve patient outcomes in the varied scenarios where it can be effective.
- 2023/07/31
- Dosing: Adult
- Dosing: Pediatric
- Reconstitution
- Administration
Note:Nitronal IV solution has been discontinued in the US for more than 1 year. Note:Hemodynamic and antianginal tolerance often develop within 24 to 48 hours of continuous nitrate administration. Nitrate-free interval (10 to 12 hours/day) is recommended to avoid tolerance development; gradually decrease dose in patients receiving nitroglycerin for...
Note:Nitronal IV solution has been discontinued in the US for more than 1 year. Note: Continuous IV infusion dosing units vary by age (mcg/kg/minute or mcg/minute); extra precautions should be taken. Tolerance to the hemodynamic and antianginal effects can develop within 24 to 48 hours of continuous use. Nitrate-free interval (10 to 12 hours/day) i...
Nitronal (glyceryl trinitrate) 1 mg/mL (temporarily available in the US): To prepare a 100 mcg/mL solution: Withdraw 25 mL D5W from a 250 mL bottle of D5W and replace volume with 25 mg (25 mL) of Nitronal. To prepare a 200 mcg/mL solution: Withdraw 50 mL D5W from a 250 mL bottle of D5W and replace volume with 50 mg (50 mL) of Nitronal.
IV: Prepare in glass bottles, EXCEL or PAB containers. Adsorption occurs to soft plastic (eg, PVC); use administration sets intended for nitroglycerin. Avoid in-line IV filters that adsorb nitroglycerin. Administer via infusion pump. Intra-anal ointment: Using a finger covering (eg, plastic wrap, surgical glove, finger cot), place finger beside 1 i...
Mechanism of action. Glyceryl trinitrate is a prodrug which must be denitrated, with the nitrite anion or a related species further reduced to produce the active metabolite nitric oxide (NO). Organic nitrates that undergo these two steps within the body are called nitrovasodilators, and the denitration and reduction occur via a variety of ...
Nov 7, 2017 · In this review, we detail the discovery of nitroglycerin and its early use in the treatment of angina; the history of the discovery of nitric oxide, its sources, and its roles; the mechanism of action, preparations, and hemodynamic and non-hemodynamic effects of the organic nitrates, as well as their biotransformation; and the clinical uses and ...
- Sanjay Divakaran, Joseph Loscalzo, Joseph Loscalzo
- 10.1016/j.jacc.2017.09.1064
- 2017
- 2017/11/11
It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its work load. When used regularly on a long-term basis, or just before exercise or a stressful event, this helps prevent angina attacks from occurring.
Jul 31, 2023 · Treatment and management. Indications, Mechanism of Action, Administration, Adverse Effects, Contraindications, Monitoring, Toxicity, Enhancing Healthcare Team Outcomes.
