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Mechanism of action. Nitroglycerin is converted by mitochondrial aldehyde dehydrogenase in smooth muscle cells to nitric oxide (NO), a potent vasodilator.
Jul 31, 2023 · Summarize the mechanism of action of nitroglycerin. Outline nitroglycerin's adverse event profile. Describe interprofessional team strategies for improving care coordination and communication to properly use nitroglycerin to improve patient outcomes in the varied scenarios where it can be effective.
- 2023/07/31
- Dosing: Adult
- Dosing: Pediatric
- Reconstitution
- Administration
Note:Nitronal IV solution has been discontinued in the US for more than 1 year. Note:Hemodynamic and antianginal tolerance often develop within 24 to 48 hours of continuous nitrate administration. Nitrate-free interval (10 to 12 hours/day) is recommended to avoid tolerance development; gradually decrease dose in patients receiving nitroglycerin for...
Note:Nitronal IV solution has been discontinued in the US for more than 1 year. Note: Continuous IV infusion dosing units vary by age (mcg/kg/minute or mcg/minute); extra precautions should be taken. Tolerance to the hemodynamic and antianginal effects can develop within 24 to 48 hours of continuous use. Nitrate-free interval (10 to 12 hours/day) i...
Nitronal (glyceryl trinitrate) 1 mg/mL (temporarily available in the US): To prepare a 100 mcg/mL solution: Withdraw 25 mL D5W from a 250 mL bottle of D5W and replace volume with 25 mg (25 mL) of Nitronal. To prepare a 200 mcg/mL solution: Withdraw 50 mL D5W from a 250 mL bottle of D5W and replace volume with 50 mg (50 mL) of Nitronal.
IV: Prepare in glass bottles, EXCEL or PAB containers. Adsorption occurs to soft plastic (eg, PVC); use administration sets intended for nitroglycerin. Avoid in-line IV filters that adsorb nitroglycerin. Administer via infusion pump. Intra-anal ointment: Using a finger covering (eg, plastic wrap, surgical glove, finger cot), place finger beside 1 i...
Aug 19, 2015 · Mechanism of action of nitroglycerin Effect on endothelial function Endothelium is the innermost lining of the blood vessels; therefore, it is sensitive to circulatory mediators that contract and relax the blood vessels.
- William E Boden, Santosh K Padala, Katherine P Cabral, Ivo R Buschmann, Mandeep S Sidhu
- 10.2147/DDDT.S79116
- 2015
- Drug Des Devel Ther. 2015; 9: 4793-4805.
Jul 31, 2023 · The mechanisms of nitroglycerin action: stenosis vasodilatation as a major component of the drug response. Circulation. 1981 Dec:64(6):1089-97 [PubMed PMID: 6794931]
Mechanism of action. Glyceryl trinitrate is a prodrug which must be denitrated, with the nitrite anion or a related species further reduced to produce the active metabolite nitric oxide (NO). Organic nitrates that undergo these two steps within the body are called nitrovasodilators, and the denitration and reduction occur via a variety of ...
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Although nitroglycerin has been used for the treatment of angina pectoris for more than a century, its mechanism of action, both biochemical and pharmacologic, remains incompletely understood. The drug relaxes various smooth muscles including vascular, ureteral, uterine, gastrointestinal, and bronchial.
