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How does nitroglycerin work?
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Mechanism of action. Nitroglycerin is converted by mitochondrial aldehyde dehydrogenase in smooth muscle cells to nitric oxide (NO), a potent vasodilator.
Jul 31, 2023 · Mechanism of Action. As with other nitrates used to treat anginal chest pain, nitroglycerin converts to nitric oxide (NO) in the body.
- 2023/07/31
Mechanism of action. Glyceryl trinitrate is a prodrug which must be denitrated, with the nitrite anion or a related species further reduced to produce the active metabolite nitric oxide (NO). Organic nitrates that undergo these two steps within the body are called nitrovasodilators, and the denitration and reduction occur via a variety of ...
Feb 17, 2020 · Mechanism of Action. Nitroglycerin forms free radical nitric oxide. In smooth muscle, nitric oxide activates guanylate cyclase which increases guanosine 3’5’ monophosphate (cGMP) leading to dephosphorylation of myosin light chains and smooth muscle relaxation.
Nov 7, 2017 · Mechanism of Action of Nitrates. Organic nitrates, such as nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate, are rapidly absorbed from several sites, such as the gastrointestinal tract, mucous membranes, and skin, depending on the preparation.
- Sanjay Divakaran, Joseph Loscalzo, Joseph Loscalzo
- 10.1016/j.jacc.2017.09.1064
- 2017
- 2017/11/11
Sep 16, 2003 · Nitroglycerin achieves its salutary action both by dilating coronary vessels and by decreasing the heart’s workload. The latter is accomplished by reducing peripheral return of blood to the heart, as well as by lessening the resistance to the outflow of blood from the heart into the main arterial circulation.
