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What is the treatment plan for inactive tuberculosis (TB)?
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Mar 22, 2023 · Skin test. A tiny amount of a substance called tuberculin is injected just below the skin on the inside of one forearm. Within 48 to 72 hours, a health care worker will check your arm for swelling at the injection site. The size of the raised skin is used to determine a positive or negative test. This test is seeing if your immune system reacts ...
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May 6, 2024 · Both inactive tuberculosis (TB) (also called latent TB infection) and active TB disease can be treated. It is important to take and finish all TB medicines exactly as your health care provider recommends. Completing treatment for inactive TB and active TB disease can protect yourself, your family and friends, and your community.
- On This Page
- Drug-Susceptible TB Disease Treatment Regimens
- 4-month Rifapentine-moxifloxacin TB Treatment Regimen
- 6- to 9-month RIPE TB Treatment Regimens
- Treatment Regimen Considerations for Specific Groups of People with TB Disease
- 6-month RIPE TB Treatment Regimen
- 9-month RIPE TB Treatment Regimen
- Evaluation and Testing Considerations for Drug-susceptible Pulmonary TB Treatment Regimens
- Related Links
•Drug-Susceptible TB Disease Treatment Regimens
•Treatment Regimen Considerations for Specific Groups of People with TB Disease
•Evaluation and Testing Considerations for Drug-susceptible Pulmonary TB Treatment Regimens
There are several treatment regimens recommended in the United States for TB disease. TB treatment can take 4, 6, or 9 months depending on the regimen. TB treatment regimens include
•New4-month Rifapentine-moxifloxacin TB Treatment Regimen
•Interim Guidance: 4-Month Rifapentine-Moxifloxacin Regimen for the Treatment of Drug-Susceptible Pulmonary Tuberculosis — United States, 2022. MMWR Morb Mortal Wkly Rep, 2022
TB treatment regimens vary in the duration of the regimen, the types of anti-TB drugs prescribed, and the dose and frequency of the drugs. The regimens described on this webpage are for the treatment of drug-susceptible pulmonary TB disease. For information about the treatment of drug-resistant TB, visit the Drug-Resistant TB webpage.
NewThe 4-month TB treatment regimen consists of
•high-dose daily rifapentine (RPT) with
•moxifloxacin (MOX),
•isoniazid (INH), and
•pyrazinamide (PZA).
The 4-month rifapentine-moxifloxacin regimen has an intensive phase of 2 months, followed by a continuation phase of 2 months and 1 week (total 17 weeks for treatment).
The 6- to 9-month RIPE TB treatment regimens consist of
•Rifampin (RIF),
•Isoniazid (INH),
•Pyrazinamide (PZA), and
•Ethambutol (EMB)
RIPE regimens for treating TB disease have an intensive phase of 2 months, followed by a continuation phase of either 4 or 7 months (total of 6 to 9 months for treatment).
Healthcare providers can choose the appropriate TB treatment regimen based on drug-susceptibility results, coexisting medical conditions (e.g., HIV, diabetes), and potential for drug-drug interactions. The State TB Control Offices and TB Centers of Excellence for Training, Education, and Medical Consultation can provide additional assistance and su...
The 6-month regimen for the treatment of drug-susceptible pulmonary TB can be used in most patients. It consists of four anti-TB drugs and is sometimes called the RIPE regimen because of the medications
•Rifampin
•Isoniazid
•Pyrazinamide
CDC recommends the 9-month regimen for the treatment of drug-susceptible pulmonary TB for the following groups:
•People with cavitary pulmonary TB caused by drug-susceptible organisms and whose sputum culture obtained at the time of completion of 2 months of treatment is positive
•People whose intensive phase of treatment did not include pyrazinamide
•People with HIV who are not receiving antiretroviral treatment (ART) during TB treatment
•People being treated with once weekly isoniazid (INH) and rifapentine and whose sputum culture obtained at the time of completion of the intensive phase is positive
(Note: Use of once-weekly therapy with INH 900 mg and rifapentine 600 mg in the continuation phase is not generally recommended. In uncommon situations where more than once-weekly directly observed therapy is difficult to achieve, once-weekly continuation phase therapy with INH 900 mg plus rifapentine 600 mg may be considered for use, but only in persons without HIV and without cavitation on chest radiography.)
The 4-month TB treatment regimen (high-dose daily rifapentine with moxifloxacin, isoniazid, and pyrazinamide) and 6-month RIPE (rifapentine, isoniazid, pyrazinamide, and ethambutol) regimen have unique considerations. The below table compares the recommended evaluation and testing considerations for the two regimens.
Dec 19, 2023 · Overview. Tuberculosis (TB) is caused by a bacterium (or germ) called Mycobacterium tuberculosis. In the United States, the majority of TB disease cases in people are caused by Mycobacterium tuberculosis. Other mycobacteria (such as Mycobacterium bovis) can also cause TB disease in people. TB usually affects the lungs.
Jun 28, 2023 · Tuberculosis prevention strategies include avoiding high risk situations and treating latent TB infections. Learn more about TB risk factors, vaccines, and more.
Nov 7, 2023 · WHO recommends a 12-component approach of collaborative TB-HIV activities, including actions for prevention and treatment of infection and disease, to reduce deaths. Impact. Tuberculosis mostly affects adults in their most productive years. However, all age groups are at risk. Over 80% of cases and deaths are in low- and middle-income countries.
