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   Can NMDA receptor antagonists help treat depression?

   • Therefore, it appears that NMDA receptor antagonists may be key to developing a new generation of improved treatments for major depression. In this review, we describe recent advances in this area, examined and analyzed current literature on the role of NMDA receptor antagonists for treatment of depression. 2. NMDA Receptor and Subunits

   NMDA Receptor Antagonists for Treatment of Depression - PMC

   www.ncbi.nlm.nih.gov/pmc/articles/PMC3816696/

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   Are NMDA receptor antagonists safe?

   • A class of drugs called NMDA (N-methyl-D-aspartate) receptor antagonists may be the answer for people with depression who don’t get relief from typical treatment. These drugs are safe and effective and tend to work more quickly than most antidepressants when taken under careful medical supervision.

   NMDA Receptor Antagonists for Major Depressive Disorder - Everyday …

   www.everydayhealth.com/depression/consumers-guide-to-nmda-receptor-antagonists-for-major-depressive-disorder/

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   Do NMDAR antagonists play a role in major depression?

   • We have critically reviewed the current literature in order to investigate the role of NMDAR antagonists in major depression. NMDAR antagonists, such as ketamine, may be considered novel and promising pharmacological options for the rapid treatment of treatment-resistant depression patients.

   NMDA receptor antagonists for depression: Critical considerations

   pubmed.ncbi.nlm.nih.gov/26247220/

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   Are NMDA receptors a new class of antidepressants?

   • It has been suggested that the NMDA receptor complex may be involved in the behavioral deficits induced by inescapable stress, and that substances capable of reducing neurotransmission at the NMDA receptor complex may represent a new class of antidepressants [ 30 ]. AP-7. ACPC. Eliprodil ( Figure 8) is an NMDAR antagonist acting at polyamine sites.

   NMDA Receptor Antagonists for Treatment of Depression - PMC

   www.ncbi.nlm.nih.gov/pmc/articles/PMC3816696/

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2. www.everydayhealth.com › depression › consumersNMDA Receptor Antagonists for Major Depressive Disorder

   www.everydayhealth.com › depression › consumers

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   Jan 31, 2023 · A class of drugs called NMDA (N-methyl-D-aspartate) receptor antagonists may be the answer for people with depression who don’t get relief from typical treatment. These drugs are safe and...

3. www.ncbi.nlm.nih.gov › pmc › articlesNMDA Receptor Antagonists for Treatment of Depression - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Apr 3, 2013 · The purpose of this review is to examine and analyze current literature on the role of NMDA receptor antagonists for treatment of depression and whether this is a feasible route in drug discovery. Keywords: NMDA receptor antagonists, depression, antidepressant-like effect, ketamine, MK-801, forced swim test

   • Author: Zeynep Ates-Alagoz, Adeboye Adejare
   • DOI: 10.3390/ph6040480

   • Publish Year: 2013
   • Published: 2013/04

4. www.nature.com › articles › s41386/023/01629-wKetamine and rapid antidepressant action: new treatments and ...

   www.nature.com › articles › s41386/023/01629-w

   Jul 24, 2023 · Ketamine is an open channel blocker of ionotropic glutamatergic N -Methyl- D -Aspartate (NMDA) receptors. The discovery of its rapid antidepressant effects in patients with...

5. pubmed.ncbi.nlm.nih.gov › 31328587An update on NMDA antagonists in depression - PubMed

   pubmed.ncbi.nlm.nih.gov › 31328587

   Expert opinion: The recent approval of esketamine by the FDA for the treatment of major depressive disorder (MDD) culminates the almost 30 years of research focused on the NMDA receptor as a target for the development of antidepressants. This action gives hope to patients who do not respond to currently available pharmacotherapy.

   • Author: Bartłomiej Pochwat, Gabriel Nowak, Bernadeta Szewczyk

   • Publish Year: 2019

6. pubmed.ncbi.nlm.nih.gov › 32616204Clinical overview of NMDA-R antagonists and clinical practice

   pubmed.ncbi.nlm.nih.gov › 32616204

   The development of NMDA receptor antagonists for treatment of depression is chronicled, from initial studies up through the recent FDA approval of intranasal esketamine as well as other newer compounds that have shown recent promise in clinical trials.

   • Author: Pasha A Davoudian, Samuel T Wilkinson

   • Publish Year: 2020

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8. www.nature.com › articles › s41380/021/01121-1Molecular mechanisms underlying the antidepressant actions of ...

   www.nature.com › articles › s41380/021/01121-1

   May 7, 2021 · Abnormalities in glutamatergic neurotransmission via the N -methyl-D-aspartate receptor (NMDAR) play a role in the pathogenesis of mood disorders, including major depressive...

9. pubmed.ncbi.nlm.nih.gov › 26247220NMDA receptor antagonists for depression: Critical ...

   pubmed.ncbi.nlm.nih.gov › 26247220

   Results: NMDAR antagonists, such as ketamine, may be considered novel and promising pharmacological options for the rapid treatment of treatment-resistant depression patients. This is in contrast to the delayed action of the currently available antidepressant medications.