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thesis of 1-phenylcyclohexylamine. The compound prepared by the alternate route (method F) was identi- cal in all respects with the one obtained prepared from Method F aC6"I NCO - CxCeH5 "2 VI phenylcyclohexene. Recently, Cristol, et ul., re- ported the isolation of the amine as its benzoyl deriva- tive via a modified Ritter reaction.
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Alkylation is an efficient method for the synthesis of 3 o and 4 o amines. However, when 1 o and 2 o amines are alkylated a mixture of products is typically produced. When ammonia is reacted with an alkylhalide an monoalkylammonium salt is formed. RX + NH 3 → RNH 3+ + X -.
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Feb 6, 2010 · Data from NIST Standard Reference Database 69: NIST Chemistry WebBook; The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment.
1-Phenylcyclohexylamine | C12H17N | CID 31862 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Synthesis is nothing more that taking an available molecule (called the starting material) and transforming it by a series of reactions into a molecule that is required for some purpose (the target). The reactions employed in the synthesis include both carbon-carbon bond forming reactions and functional group transformations.
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A series of phencyclidine homologs was synthesized by reductive cyclization of substituted ω-chlorine-substituted l-N- [l- (p-hydroxybenzyl)cyclohexyl]amides with LiAlH4 by characterized and tested for neurotropic activity. Expand. 1. Synthesis and biological activity of cyclohexylamine derivatives. V. A. Glushkov O. S. P’yankova. +4 authors.
Synthesis of PCP from PCA via 1-phenylcyclohexanol (PCOH) The PCOH starting material can be purchased or prepared by reaction of phenyllithium or phenyl grignard with cyclohexanone. This alcohol is then be transformed into the amine by reaction with sodium azide (~90% yield) followed by reduction.
