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What is drug elimination?
How are drugs eliminated from the body?
What is drug elimination in pharmacokinetic ADME?
Jul 4, 2023 · Drug elimination is the sum of the processes of removing an administered drug from the body. In the pharmacokinetic ADME scheme (absorption, distribution, metabolism, and excretion), it is frequently considered to encompass both metabolism and excretion. Hydrophobic drugs, to be excreted, must undergo metabolic modification making them more polar.
Pharmacokinetics is the term that describes the four stages of absorption, distribution, metabolism, and excretion of drugs. Drugs are medications or other substances that have a physiological effect when introduced to the body.
- 2023
Reviewed/Revised Jun 2022 | Modified Sep 2022. VIEW PROFESSIONAL VERSION. Drug elimination is the removal of drugs from the body. (See also Introduction to Administration and Kinetics of Drugs.) All drugs are eventually eliminated from the body. They may be eliminated after being chemically altered (metabolized), or they may be eliminated intact.
Biliary excretion eliminates substances from the body only to the extent that enterohepatic cycling is incomplete—when some of the secreted drug is not reabsorbed from the intestine. Drug Excretion and Clinical Pharmacology - Learn about from the Merck Manuals - Medical Professional Version.
Drugs can be metabolized by oxidation, reduction, hydrolysis, hydration, conjugation, condensation, or isomerization; whatever the process, the goal is to make the drug easier to excrete. The enzymes involved in metabolism are present in many tissues but generally are more concentrated in the liver.
Okay, now let’s focus on a process called elimination, which is often confused with the process of excretion. Elimination is the removal of a medication from the body. Now this can be accomplished through metabolism, where the medication is broken down into inactive metabolites, or through excretion which is when the intact medication is ...
