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   What is septic shock & sepsis?

   • Sepsis: Life-threatening organ dysfunction caused by a dysregulated host response to infection Septic shock: Sepsis with circulatory and cellular/metabolic abnormalities profound enough to substantially increase mortality Sepsis: Suspected or documented infection and an acute increase of ≥ 2 SOFA points (a proxy for organ dysfunction)

   Consensus Definitions for Sepsis and Septic Shock - JAMA

   sites.jamanetwork.com/sepsis/

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   Where can I find information about sepsis & septic shock management?

   • Visit Sepsis Alliance’s informational webpage, SEP-1: Guiding Lifesaving Care. “SEP-1” is shorthand for “The Severe Sepsis and Septic Shock Management Bundle.” It lays out guidelines for frontline hospital clinicians fighting sepsis. SEP-1 focuses on timely sepsis recognition and early intervention with lifesaving therapies.

   The SEP-1 Measure: What Is It, and How Does It Impact Sepsis Patients

   www.sepsis.org/news/the-sep-1-measure-what-is-it-and-how-does-it-impact-sepsis-patients-their-families/

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   What is SEP-1 & why is it important for patients with sepsis?

   • What is SEP-1, and why is it important for patients with sepsis? SEP-1 is a process for healthcare professionals in hospitals to follow for every patient with severe sepsis or septic shock. It focuses on timely sepsis recognition and early intervention with lifesaving therapies, like a fast first dose of broad-spectrum antibiotics.

   SEP-1: Guiding Lifesaving Care | Sepsis Alliance

   www.sepsis.org/protect-sep-1/

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   Do we need a reexamination of sepsis and septic shock?

   • Considerable advances have since been made into the pathobiology (changes in organ function, morphology, cell biology, biochemistry, immunology, and circulation), management, and epidemiology of sepsis, suggesting the need for reexamination. ObjectiveTo evaluate and, as needed, update definitions for sepsis and septic shock.

   Consensus Definitions for Sepsis and Septic Shock

   jamanetwork.com/journals/jama/fullarticle/2492881

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2. www.sepsis.org › news › the-sep-1-measure-what-is-itThe SEP-1 Measure: What Is It, and How Does It Impact Sepsis ...

   www.sepsis.org › news › the-sep-1-measure-what-is-it

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   Jun 22, 2021 · “SEP-1” is shorthand for “The Severe Sepsis and Septic Shock Management Bundle.” It lays out guidelines for frontline hospital clinicians fighting sepsis. SEP-1 focuses on timely sepsis recognition and early intervention with lifesaving therapies.

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4. jamanetwork.com › journals › jamaConsensus Definitions for Sepsis and Septic Shock

   jamanetwork.com › journals › jama

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   Septic shock should be defined as a subset of sepsis in which particularly profound circulatory, cellular, and metabolic abnormalities are associated with a greater risk of mortality than with sepsis alone.

   • Author: Mervyn Singer, Clifford S. Deutschman, Christopher Warren Seymour, Manu Shankar-Hari, Djillali Annan...

   • Publish Year: 2016

5. www.ncbi.nlm.nih.gov › pmc › articlesThe Third International Consensus Definitions for Sepsis and ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Feb 2, 2016 · Septic shock should be defined as a subset of sepsis in which particularly profound circulatory, cellular, and metabolic abnormalities are associated with a greater risk of mortality than with sepsis alone.

   • Author: Mervyn Singer, Clifford S. Deutschman, Christopher Warren Seymour, Manu Shankar-Hari, Djillali Annan...
   • DOI: 10.1001/jama.2016.0287

   • Publish Year: 2016
   • Published: 2016/02/02

6. sites.jamanetwork.com › sepsisConsensus Definitions for Sepsis and Septic Shock - JAMA

   sites.jamanetwork.com › sepsis

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   The Task Force recommended that sepsis and septic shock be defined as follows: Definitions: Sepsis: Life-threatening organ dysfunction caused by a dysregulated host response to infection Septic shock: Sepsis with circulatory and cellular/metabolic abnormalities profound enough to substantially increase mortality

7. www.ccjm.org › content › 87/1/53Sepsis and septic shock: Guideline-based management

   www.ccjm.org › content › 87/1/53

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   Jan 1, 2020 · Septic shock was described as hypotension and organ dysfunction that persisted despite volume resuscitation, necessitating vasoactive medication, and with 2 or more of the SIRS criteria listed above. In 2001, definitions were updated with clinical and laboratory variables. 5.

   • Author: Siddharth Dugar, Chirag Choudhary, Abhijit Duggal

   • Publish Year: 2020

8. www.mayoclinic.org › diseases-conditions › sepsisSepsis - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org › diseases-conditions › sepsis

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   Feb 10, 2023 · Sepsis is a serious condition in which the body responds improperly to an infection. The infection-fighting processes turn on the body, causing the organs to work poorly. Sepsis may progress to septic shock. This is a dramatic drop in blood pressure that can damage the lungs, kidneys, liver and other organs.