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Does uveal melanoma cause distant metastasis?
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Mar 5, 2019 · Median overall survival (OS) in patients with uveal melanoma liver metastasis ranges between 14 and 28 months by recent reports, depending on the method of treatment [4, 5, 6]. Treatment options for metastatic liver lesions include systemic therapy, and local therapy to the liver [ 7 ].
Aug 14, 2023 · Uveal melanoma has a high tendency to spread to other organs. Liver metastases occur in up to 95% of patients with metastatic disease, and these lesions are often unresectable. According to the National Cancer Institute, the mean age-adjusted incidence of uveal melanoma in the U.S. is 4.3 new cases per 1 million people.
Mar 13, 2023 · Metastatic uveal melanoma can spread to the liver. In fact, the liver is the most common organ in the body affected by spread of this type of eye cancer. In 90% to 95% of cases, the...
Uveal melanoma, the most common primary intraocular tumor, 1–4 has an associated approximate 40% risk of metastasizing to the liver within 10 years of diagnosis of the primary tumor. 1 Hepatic metastases, which occur in 95% of patients with metastatic uveal melanoma, 5 result in death in almost all cases. 6,7 It is important to understand the ...
- Hans E. Grossniklaus
- 2013
Jan 4, 2023 · Treatment of primary uveal melanoma with radiotherapy, enucleation or other modalities achieves local control in more than 90% of patients, although 40% or more ultimately develop distant...
Understanding Uveal Melanoma Metastasis to the Liver: The Zimmerman Effect and the Zimmerman Hypothesis. During the 1970s, it became evident that a substantial number of persons with uveal melanoma died of metastases, primarily to the liver, after enucleation of the eye containing the melanoma.
Apr 3, 2024 · Despite effective treatment of the primary site, the risk of distant metastasis among patients with uveal melanoma is up to 50 percent (depending on the genetic subtype [ 4,7 ]). (See "Initial management of uveal and conjunctival melanomas", section on 'Posttreatment systemic surveillance' .)
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related to: uveal melanoma metastatic to the liverState-of-the-Art, Evidence-Based Treatment Plans for Those with Metastatic Liver Cancer. UPMC is Committed to Providing You with an Exceptional Level of Cancer Care.
FDA Approved prescription medication for treatment of metastatic uveal melanoma. Learn about a treatment option for Metastatic Uveal Melanoma.
Learn more about a locally advanced or metastatic urothelial cancer treatment option. Patient support program. Important Safety Info. Efficacy info.
