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The nucleus accumbens and the ventral tegmental area are the primary sites where addictive drugs act. The following are commonly considered to be addictive: cocaine, alcohol, opioids, nicotine, cannabinoids, amphetamine, and their analogs. These drugs alter the neuromodulatory influence of dopamine on the processing of reinforcement signals by ...
Oct 30, 2023 · The nucleus accumbens receives dopaminergic projections from the ventral tegmental area and substantia nigra of the midbrain. This connection forms part of a major dopaminergic pathway called the mesolimbic pathway (reward pathway), which connects the VTA with regions of the limbic system including the nucleus accumbens, hypothalamus, amygdala ...
- Medical Content
- 22 min
Apr 27, 2022 · In this review, we present the most recent evidence for the ventral tegmental area (VTA) and nucleus accumbens (NAc) to serve as extra-SCN oscillators and highlight studies that illustrate the functional significance of the VTA’s and NAc’s inherent circadian properties as they relate to reward-processing, drug abuse, and vulnerability to ...
- 10.3389/fphys.2022.886704
- 2022
- Front Physiol. 2022; 13: 886704.
Jan 5, 2017 · Ventral tegmental area (VTA) dopamine neurons (which we here define as those neurons that express the dopamine-producing enzyme tyrosine hydroxylase (TH) and release dopamine ( Box 1) are...
- Marisela Morales, Elyssa B. Margolis
- 2017
Oct 18, 2019 · The nucleus accumbens (NAc) is a subcortical brain structure located within the ventral striatum. It is often referred to as the pleasure center of the brain for its primary role in positive affect and feelings of reward, but this is an incomplete description.
- Haley N Harris, Yuan B Peng
- 10.4103/1673-5374.266909
- 2020
- Neural Regen Res. 2020 Apr; 15(4): 597-605.
Aug 12, 2021 · Article. Published: 12 August 2021. Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement. Ream...
Aug 14, 2013 · A recent literature has identified important structural and functional alterations within the brain's reward circuitry — particularly in the ventral tegmental area–nucleus accumbens...
