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May 20, 2022 · The ventral tegmental area (VTA) is well known for regulating reward consumption, learning, memory, and addiction behaviors through mediating dopamine (DA) release in downstream regions. Other than DA neurons, the VTA is known to be heterogeneous and contains other types of neurons, including glutamate neurons.
Thus, the ventral tegmental area is reciprocally connected with a wide range of structures throughout the brain suggesting that it has a role in the control of function in the phylogenetically newer and highly developed neocortex, as well as that of the phylogenetically older limbic areas.
Jan 5, 2017 · Nature Reviews Neuroscience - Neurons in the ventral tegmental area (VTA) are highly heterogeneous and project to a range of different brain regions. Morales and Margolis summarize recent...
- Marisela Morales, Elyssa B. Margolis
- 2017
The ventral tegmental area, or VTA, is in the midbrain, situated adjacent to the substantia nigra. Although it contains several different types of neurons, it is primarily characterized by its dopaminergic neurons, which project from the VTA throughout the brain.
The dopaminergic pathway mostly involved in reward is the so-called mesolimbic system, which is formed by projections of midbrain dopamine neurons of the ventral tegmental area (VTA) to the striatum, prefrontal cortex, amygdala, hippocampus, and many other structures of the limbic system.
- 10.1007/978-3-030-81147-1_4
- 2021
Sep 14, 2023 · Central to this system are the Ventral Tegmental Area (VTA) and the Nucleus Accumbens (NAc). When a rewarding stimulus is perceived, dopamine is released from the VTA, acting on the NAc, leading to feelings of pleasure. Dysfunctions in this pathway can underlie addiction and other behavioral disorders.
The ventral tegmental area (VTA) located in the midbrain controls diverse behavioral repertoire, including reward processing, aversion, stress modulation, drug addiction, learning, and memory ( Haber and Fudge, 1997; Ikemoto, 2007; Arias-Carrion et al., 2010; Polter and Kauer, 2014 ).
