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Which antibiotics should be used for Pseudomonas infection?
Which antipseudomonal drug combination therapy is best for a pseudomonal infection?
Can antibiotics be used to treat Pseudobacter aeruginosa infections?
What should I do if I have a Pseudomonas aeruginosa infection?
Feb 6, 2024 · This organism is important because it is often antibiotic resistant and can cause severe hospital-acquired infections associated with a high mortality rate, especially in immunocompromised hosts. The principles of antimicrobial treatment of infections caused by P. aeruginosa will be reviewed here.
- Overview
- Symptoms and Causes
- Diagnosis and Tests
- Management and Treatment
- Prevention
- Outlook / Prognosis
- Living With
A Pseudomonas aeruginosa infection is a condition that can affect your skin, blood, lungs, GI tract and other parts of your body. Pseudomonas bacteria are common in the environment, especially water, soil and produce. Symptoms vary according to where the infection is in your body. Treatment usually includes at least one type of antibiotic.
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OverviewSymptoms and CausesDiagnosis and TestsManagement and TreatmentPreventionOutlook / PrognosisLiving With
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What are the signs and symptoms of a Pseudomonas aeruginosa infection?
Symptoms vary according to where the Pseudomonas aeruginosa infection affects your body. Your symptoms may include: Blood Chills. Feeling very tired (fatigue). Fever. Joint pain. Low blood pressure (hypotension). Muscle pain. Ear Earache. Fluid that comes out of your ear (discharge). Itching. Swelling. Hearing loss. GI tract Headache. Diarrhea. Nausea and vomiting. Eye Inflammation. Pain. Pus. Red eyes. Swelling. Sudden vision loss. Lung Chills. Cough. Difficulty breathing. Fever. Skin Discolored (red, brown or purple) bumps. Foul-smelling, clear or pink fluid that drains from a wound (draining wound). Itchiness. White or yellow pus-filled bumps (abscess). Urinary tract Having to pee suddenly or uncontrollably (urge incontinence). Leaking pee when you don’t mean to (urinary incontinence). Pain around your pelvic area. Pain when you pee (dysuria). Peeing more than usual (frequent urination).
What causes a Pseudomonas infection?
Many types of bacteria from the genus (grouping) Pseudomonas cause a Pseudomonas infection — the most common type to cause infection is P. aeruginosa. Pseudomonas bacteria can grow and spread in many different ways, including through: Water, including from sinks, bathtubs, pools, hot tubs, humidifiers and kitchens. Soil. Food. Contaminated medical devices, including a ventilator or urinary catheter. Skin contact.
What are the complications of Pseudomonas aeruginosa infection?
Pseudomonas aeruginosa bacteria can cause a potentially fatal infection that spreads to other areas of your body and triggers other serious conditions, including sepsis and organ failure. A Pseudomonas aeruginosa infection can also be resistant to antibiotics. That means that common antibiotics that healthcare providers prescribe to treat an infection can’t kill the bacteria. If you take antibiotics to treat a Pseudomonas aeruginosa infection, you may also be more likely to get a Clostridioides difficile (C. diff) infection.
How is a Pseudomonas aeruginosa infection diagnosed?
A healthcare provider can diagnose a Pseudomonas aeruginosa infection after reviewing your medical history, asking about your symptoms and conducting a physical examination, which may include: Using a stethoscope to listen to your heart and lungs (auscultation). Feeling your abdomen. Examining your skin. Looking at your eyes. They’ll also order tests to confirm their diagnosis.
How is a Pseudomonas aeruginosa infection treated?
A healthcare provider will usually recommend antibiotics to treat a Pseudomonas aeruginosa infection. They may prescribe one or more of the following: Aztreonam. Carbapenems. Ceftazidime. Ciprofloxacin. Gentamicin. Ticarcillin. Ureidopenicillins. You may take these antibiotics orally (as a pill with water), topically (as a cream or gel you apply to your skin), via eye drops or intravenously (through a needle in a vein). You may have to take antibiotics for several weeks or even months, depending on the severity of your infection. Pseudomonas aeruginosa infections are growing resistant to different types of antibiotics, especially if you get an infection from a hospital or other healthcare facility. It’s very important that you take the antibiotics exactly as your provider prescribes and finish the full course, even if you feel better. If you don’t, a Pseudomonas aeruginosa infection can return and be more challenging to treat.
How soon after treatment will I feel better?
If you have a mild Pseudomonas aeruginosa infection, you should start to feel better a few days after starting treatment. It may take weeks or even months to recover after a severe infection. Care at Cleveland Clinic Find a Primary Care Provider Schedule an Appointment
Can a Pseudomonas aeruginosa infection be prevented?
You can help lower your risk of developing a Pseudomonas aeruginosa infection with the following tips: Wash your hands regularly. Washing your hands with antibacterial soap and clean water is the best way to prevent an infection. If you can’t wash your hands, use an alcohol-based hand sanitizer. Wash fruits and vegetables. Thoroughly wash fruits and vegetables with clean water and, if possible, a fruit/vegetable soap. Drink clean water. If you don’t have clean water available, be sure to drink bottled, canned, boiled or chemically treated water. Thoroughly clean surfaces. Use disinfecting products to clean high-touch surfaces. Avoid dirty hot tubs and pools. Make sure you regularly treat hot tub or pool water with chlorine.
What can I expect if I have a Pseudomonas aeruginosa infection?
In many cases, the outlook for a Pseudomonas aeruginosa infection is good if you have a healthy immune system. Minor cases usually clear up within a few days with proper treatment. But you must take your entire course of antibiotics. If you don’t, it can be much more challenging to treat. A Pseudomonas aeruginosa infection can be severe and even fatal if you have a weakened immune system. You may need to take more than one type of antibiotic. And you may need to take the antibiotics over a long period to stop the infection from getting worse.
When should I see a healthcare provider?
Since a Pseudomonas aeruginosa infection can become serious very quickly if you have a weakened immune system, it’s important that you call a healthcare provider right away if you have any signs of an infection or your symptoms don’t improve after treatment.
What questions should I ask a healthcare provider?
How did I get a Pseudomonas aeruginosa infection? If I don’t have a Pseudomonas aeruginosa infection, what other condition might I have? What treatment do you recommend? Do I need more than one type of antibiotic? What should I do if I forget to take a dose of my antibiotic? Are there any signs I should look for that indicate the infection is getting worse? A note from Cleveland Clinic Pseudomonas bacteria exist throughout the world in wet environments like water and soil. They may even live on your skin, though they might not cause an infection. If you have a healthy immune system, Pseudomonas aeruginosa infections are usually minor — you may not even notice any symptoms. But the infections can be severe if you have a weakened immune system. Speak to a healthcare provider if you have signs of a Pseudomonas aeruginosa infection. They can diagnose an infection and prescribe the most appropriate antibiotics to manage the bacteria so it doesn’t get worse. Medically Reviewed Last reviewed by a Cleveland Clinic medical professional on 07/21/2023. Learn more about our editorial process.
Cefiderocol, a new cephalosporin, shows very promising results against P. aeruginosa. Currently, combination therapy is only recommended in limited scenarios. Extended-infusion of β-lactams exhibit clinical benefit. Bacteriophage therapy is a growing field of interest and may have an impactful effect on the treatment of resistant P. aeruginosa.
- Dima Ibrahim, Jean-Francois Jabbour, Souha S Kanj
- 2020
Dec 15, 2022 · Two antipseudomonal drug combination therapy (eg, a beta-lactam antibiotic with an aminoglycoside) is usually recommended for the initial empiric treatment of a pseudomonal infection,...
Feb 16, 2023 · Based on the presence of risk factors for MDR/XDR infections and local epidemiology, where large proportions of strains are resistant to classic beta-lactams, the recommended empirical treatment for suspected P. aeruginosa infections is based on ceftolozane-tazobactam or ceftazidime-avibactam.
- 10.3390/antibiotics12020399
- 2023/02
- Antibiotics (Basel). 2023 Feb; 12(2): 399.
Mar 3, 2023 · Pseudomonas infection can be treated with a combination of an antipseudomonal beta-lactam (eg, penicillin or cephalosporin) and an aminoglycoside. Carbapenems (eg, imipenem, meropenem) with...
May 29, 2018 · Clinical approaches to patients with bacteremia, ventilator-associated pneumonia, urinary tract infections and skin soft tissue infections are discussed. Antibiotic combinations are reviewed as well as an analysis of pharmacokinetic and pharmacodynamic parameters to optimize P. aeruginosa treatment.
