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  1. Mar 6, 2024 · A skin rash is a common side effect of amoxicillin. It's important to know that although these rashes can be worrisome, they're usually not cause for alarm. Allergies to amoxicillin and other antibiotics are undoubtedly possible. However, many viruses can cause non-allergic rashes in people who take amoxicillin.

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    Signs and symptoms of penicillin allergy often occur within an hour after taking the drug. Less commonly, reactions can occur hours, days or weeks later.

    Penicillin allergy signs and symptoms may include:

    •Skin rash

    •Hives

    •Itching

    •Fever

    See your doctor as soon as possible if you experience signs or symptoms of penicillin allergy. It's important to understand and discuss what is an allergic reaction, what is a typical side effect and what you can tolerate in taking a medication.

    Call 911 or emergency medical help if you experience signs of a severe reaction or suspected anaphylaxis after taking penicillin.

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    Penicillin allergy occurs when your immune system becomes hypersensitive to the drug — mistakenly reacting to the drug as a harmful substance, as if it were a viral or bacterial infection.

    Before the immune system can become sensitive to penicillin, you have to be exposed to the medication at least once. If and when your immune system misidentifies penicillin as a harmful substance, it develops an antibody to the drug.

    The next time you take the drug, these specific antibodies flag it and direct immune system attacks on the substance. Chemicals released by this activity cause the signs and symptoms associated with an allergic reaction.

    Previous exposure to penicillin may not be obvious. Some evidence suggests that trace amounts of it in the food supply may be sufficient for a person's immune system to create an antibody to it.

    While anyone can have an allergic reaction to penicillin, a few factors can increase your risk. These include:

    •A history of other allergies, such as food allergy or hay fever

    •Allergic reaction to another drug

    •A family history of drug allergy

    •Increased exposure to penicillin, because of high doses, repetitive use or prolonged use

    •Certain illnesses commonly associated with allergic drug reactions, such as infection with human immunodeficiency virus (HIV) or the Epstein-Barr virus

    If you have a penicillin allergy, the simplest prevention is to avoid the drug. Steps you can take to protect yourself include the following:

    •Inform health care workers. Be sure that your penicillin allergy or other antibiotic allergy is clearly identified in your medical records. Inform other health care professionals, such as your dentist or any medical specialist.

    •Wear a bracelet. Wear a medical alert bracelet that identifies your drug allergy. This information can ensure proper treatment in an emergency.

    Request an appointment

    By Mayo Clinic Staff

    Sep 29, 2021

    •Why should I be evaluated for a penicillin allergy?

    •Mayo Clinic Minute: Penicillin allergy? Maybe not

  2. Apr 4, 2022 · If you’re taking an antibiotic (or any other new medication), keep an eye out for these signs: Blistered or peeling skin. Blurry vision or other vision problems. Dizziness. Hives. Red, itchy, flaky or swollen skin. Severe nausea or vomiting. Severe swelling or itching. Swelling of the face, lips or tongue.

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  4. Sep 29, 2021 · The following interventions may be used to treat the symptoms of an allergic reaction to penicillin: Withdrawal of the drug. If your doctor determines that you have a penicillin allergy — or likely allergy — discontinuing the drug is the first step in treatment. Antihistamines. Your doctor may prescribe an antihistamine or recommend an over ...

  5. In cases of a positive penicillin test, either the skin prick or intradermal test will produce a red, raised bump, signifying the presence of an allergy to the medication. Penicillins need to be avoided and a different antibiotic will be needed to treat infections. If a penicillin is needed, a desensitization procedure can be performed under ...

  6. Jan 11, 2023 · Antibiotics in the penicillin class are one of the most commonly prescribed antibiotics and include many individual medications, such as penicillin G, amoxicillin, nafcillin, oxacillin, dicloxacillin, flucloxacillin, ampicillin, carbenicillin, ticarcillin, and piperacillin-tazobactam. Penicillins are part of a larger family of antibiotics known ...

  7. Mar 22, 2023 · A penicillin allergy is a common allergy. It occurs when your immune system reacts negatively to the antibiotic penicillin. You may experience a skin rash, swelling or difficulty breathing shortly after taking penicillin. An allergic reaction can be a medical emergency, so contact your healthcare provider or call 911 if symptoms are severe.

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