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The strength of the evidence for carcinogenicity from human and experimental animal data is evaluated and classified into one of the following categories: sufficient evidence, limited evidence, inadequate evidence, or evidence suggesting lack of carcinogenicity.
Each Monograph presents a description of a carcinogenic agent and how people are exposed, critical overviews of the epidemiological studies and animal cancer bioassays, and a concise review of the agent's toxicokinetics, plausible mechanisms of carcinogenesis, and potentially susceptible populations, and life-stages.
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Jun 16, 2023 · This infographic presents the categories used by the IARC Monographs on the Identification of Carcinogenic Hazards to Humans to classify a substance according to the level of certainty that the substance can cause cancer.
- Abstract
- Motivation and Process For Preamble Revision
- Key Changes in The Revised Preamble
- Funding
- Notes
For nearly 50 years, the Monographs program of the International Agency for Research on Cancer (IARC) has been a premier global resource for identifying agents that can cause cancer. The identification of carcinogenic hazards is a necessary initial step in cancer prevention. National and international authorities and organizations use information o...
Since 2006, substantial growth has occurred in the scientific understanding of factors contributing to carcinogenicity as well as in the development of methods for information gathering, evidence assessment, and integration. In 2018, the IARC convened an “Advisory Group to Recommend an Update to the Preamble,” with broad expertise across multiple d...
General Procedures
The advisory group encouraged the IARC to clarify the purpose and scope of the Monographs evaluations. In this regard, the name of the Monographs series has been changed to the IARC Monographs on the Identification of Carcinogenic Hazards to Humans. This change, although semantic in nature, reflects the important distinction between hazard and risk: Hazard refers to the strength of the evidence that an agent is a carcinogen, whereas risk refers to the probability that a given exposure to a ca...
Scientific Review and Evaluation
The revised Preamble defines how the principles of systematic review (eg, formal consideration of quality of the studies, such as design and methodology, and the reporting of results that are tailored to each stream of evidence and the types of studies available) apply to IARC assessments and how evaluations are reached to clearly articulate the rationales for expert judgments. At the same time, it is designed to be flexible enough to enable incorporation of further scientific advances as the...
This work was supported by the German Ministry of Health and the International Agency for Research on Cancer.
The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the International Agency for Research on Cancer, the US Centers for Disease Control and Prevention, the US Food and Drug Administration, the US Environmental Protection Agency, or the US National Institute of Environmental...
- Jonathan M Samet, Weihsueh A Chiu, Vincent Cogliano, Jennifer Jinot, David Kriebel, Ruth M Lunn, Fre...
- 2020
Agents are assigned to either Group 2A (probably carcinogenic to humans) or Group 2B (possibly carcinogenic to humans) on the basis of epidemiological and experimental evidence of carcinogenicity and mechanistic and other relevant data.
IARC Monographs on the Identification of Carcinogenic Hazards to Humans. IARC Monographs evaluate the carcinogenicity of anthracene, 2-bromopropane, butyl methacrylate, and dimethyl hydrogen phosphite. International Childhood Cancer Day 2023 – Dr Eva Steliarova-Foucher.
The IARC Monographs identify environmental factors that are carcinogenic hazards to humans. These include chemicals, complex mixtures, occupational exposures, physical agents, biological agents, and lifestyle factors.
