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   How does the IARC select a carcinogenic agent?

   • The IARC staff makes the final selection of agents for review by taking into account the prevalence and intensity of exposure (of both occupational groups and the general population) and availability of sufficient literature for an evaluation of carcinogenicity, as well as advice from the Advisory Groups.

   IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Hum…

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4455595/

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   Why did IARC create a list of agents that cause cancer?

   • Shortly after IARC’s establishment, its parent entity, the World Health Organization (WHO), asked IARC to prepare a list of agents known to cause cancer in humans. IARC recognized the need for a systematic process to determine which agents should be listed.

   IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Hum…

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4455595/

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   What are IARC assessments of carcinogenicity based on?

   • IARC assessments of carcinogenicity are based on, and necessarily limited to, scientific evidence available at the time of the review. The evidence comes from epidemiologic studies, animal bioassays, pharmacokinetic/mechanistic experiments, and surveys of human exposure.

   IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Hum…

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4455595/

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   Do IARC Working Groups review evidence of carcinogenicity?

   • Although IARC working groups have always conducted comprehensive reviews of evidence of carcinogenicity, advances in systematic review methods ( 10–15) provide a basis for more specific guidance to working group members, thereby enhancing consistency and transparency.

   The IARC Monographs: Updated Procedures for Modern and Transparent

   www.ncbi.nlm.nih.gov/pmc/articles/PMC6968684/

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2. immunologic.substack.com › p › what-doesWhat does carcinogenic really mean? - by Dr. Andrea Love

   immunologic.substack.com › p › what-does

   Apr 8, 2024 · Carcinogenic means that the exposure has the potential to cause cancer, not that it does under all circumstances. It also means something different depending on who is applying the term. Claims circulating about risks of cancer are a result of the International Agency for Research on Cancer (IARC).

3. www.ncbi.nlm.nih.gov › pmc › articlesIARC Monographs: 40 Years of Evaluating Carcinogenic Hazards ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Feb 24, 2015 · Group 2B: The agent is possibly carcinogenic to humans. This category is used for agents for which there is limited evidence of carcinogenicity in humans and less than sufficient evidence of carcinogenicity in experimental animals.

   • Author: Neil Pearce, Aaron Blair, Paolo Vineis, Wolfgang Ahrens, Aage Andersen, Josep M. Anto, Bruce K. Arms...

   • Publish Year: 2015

4. monographs.iarc.who.int › human_cancer_knownHuman Cancer: Known Causes and Prevention by Organ Site

   monographs.iarc.who.int › human_cancer_known

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   Jan 23, 2024 · Human Cancer: Known Causes and Prevention by Organ Site. This poster presents the target organs for all agents classified as carcinogenic to humans (Group 1) by the IARC Monographs programme (in red text on the poster), and for the interventions showing sufficient evidence of a cancer-preventive effect in the IARC Handbooks of Cancer Prevention ...

5. www.ncbi.nlm.nih.gov › pmc › articlesThe IARC Monographs: Updated Procedures for Modern and ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Sep 9, 2019 · The agent is probably carcinogenic to humans (group 2A): This category generally applies when the working group has made at least two of the following evaluations, including at least one that involves either exposed humans or human cells or tissues:

   • Author: Jonathan M Samet, Weihsueh A Chiu, Vincent Cogliano, Jennifer Jinot, David Kriebel, Ruth M Lunn, Fre...

   • Publish Year: 2020

6. www.iarc.who.int › infographics › iarc-monographsIARC Monographs hazard classification – IARC

   www.iarc.who.int › infographics › iarc-monographs

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   Jun 16, 2023 · This infographic presents the categories used by the IARC Monographs on the Identification of Carcinogenic Hazards to Humans to classify a substance according to the level of certainty that the substance can cause cancer.

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8. monographs.iarc.who.int › home › iarc-monographsIARC Monographs – General Information – IARC Monographs on ...

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   Since 1971, more than 1000 agents have been evaluated, of which more than 500 have been identified as carcinogenic, probably carcinogenic, or possibly carcinogenic to humans. Read the IARC Monographs Q&A for answers to commonly asked questions on the evaluation process.

9. www.iarc.who.intIARC – INTERNATIONAL AGENCY FOR RESEARCH ON CANCER

   www.iarc.who.int

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   Maternal orphans due to cancer: the intergenerational impact of cancer deaths in women (IARC Evidence Summary Brief No. 5)