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What is viral neuraminidase?
How does neuraminidase work?
Is neuraminidase important for the initiation of influenza virus infection?
What are neuraminidase enzymes?
Viral neuraminidase is a type of neuraminidase found on the surface of influenza viruses that enables the virus to be released from the host cell. Neuraminidases are enzymes that cleave sialic acid (also called neuraminic acid ) groups from glycoproteins .
Drugs called neuraminidase inhibitors, which include oseltamivir (Tamiflu) and zanamivir (Relenza), inhibit the release of influenza A and B viruses from host cells.
- Kara Rogers
Jan 29, 2019 · Although the influenza A virus surface glycoprotein neuraminidase (NA) has been studied mainly in the context of its role in viral release from cells, accumulating evidence suggests it plays an important, multifunctional role in virus infection and fitness.
- Julie L. McAuley, Brad P. Gilbertson, Sanja Trifkovic, Sanja Trifkovic, Lorena E. Brown, Jennifer L....
- 10.3389/fmicb.2019.00039
- 2019
- Front Microbiol. 2019; 10: 39.
The structure of the influenza virus neuraminidases, the spatial organization of their active site, the mechanism of carbohydrate chains desialylation by neuraminidase, and its role in the influenza virus function at different stages of the viral infectious cycle are considered in this review.
- Y A Shtyrya, L V Mochalova, N V Bovin
- Acta Naturae. 2009 Jul; 1(2): 26-32.
- 2009
- 2009/07
Mar 30, 2023 · Influenza A viruses are divided into subtypes based on two proteins on the surface of the virus: hemagglutinin (H) and neuraminidase (N). There are 18 different hemagglutinin subtypes and 11 different neuraminidase subtypes (H1 through H18 and N1 through N11, respectively).
Feb 27, 2019 · Neuraminidases are expressed on the viral surface as tetramers and serve to promote the release of progeny viruses from the infected cells as well as the penetration through host mucus by desialylation of viral and cellular surface glycans [ 8, 9 ].
The best-known neuraminidase is the viral neuraminidase, a drug target for the prevention of the spread of influenza infection. Viral neuraminidase was the first neuraminidase to be identified. It was discovered in 1957 by Alfred Gottschalk at the Walter and Eliza Hall Institute in Melbourne. [1] .
