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- Viral neuraminidase cleaves terminal sialic acid residues from glycan structures on the surface of the infected cell. This promotes the release of progeny viruses and the spread of the virus from the host cell to uninfected surrounding cells.
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Neuraminidase cleaves the sialic acid molecule, thereby freeing the virus to infect other cells in the host organism. Antibodies against neuraminidase that are generated by the host’s immune system following infection bind to a portion of the neuraminidase antigen known as an epitope .
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Viral neuraminidase cleaves terminal sialic acid residues from glycan structures on the surface of the infected cell. This promotes the release of progeny viruses and the spread of the virus from the host cell to uninfected surrounding cells. Neuraminidase also cleaves sialic acid residues from viral proteins, preventing aggregation of viruses.
Jan 29, 2019 · Although the influenza A virus surface glycoprotein neuraminidase (NA) has been studied mainly in the context of its role in viral release from cells, accumulating evidence suggests it plays an important, multifunctional role in virus infection and fitness.
- Julie L. McAuley, Brad P. Gilbertson, Sanja Trifkovic, Sanja Trifkovic, Lorena E. Brown, Jennifer L....
- 10.3389/fmicb.2019.00039
- 2019
- Front Microbiol. 2019; 10: 39.
The structure of the influenza virus neuraminidases, the spatial organization of their active site, the mechanism of carbohydrate chains desialylation by neuraminidase, and its role in the influenza virus function at different stages of the viral infectious cycle are considered in this review.
- Y A Shtyrya, L V Mochalova, N V Bovin
- Acta Naturae. 2009 Jul; 1(2): 26-32.
- 2009
- 2009/07
The viral neuraminidases are frequently used as antigenic determinants found on the surface of the influenza virus. Some variants of the influenza neuraminidase confer more virulence to the virus than others. Other homologues are found in mammalian cells, which have a range of functions.
Feb 27, 2019 · Neuraminidases are expressed on the viral surface as tetramers and serve to promote the release of progeny viruses from the infected cells as well as the penetration through host mucus by desialylation of viral and cellular surface glycans [ 8, 9 ].
Aug 26, 2019 · Influenza neuraminidase (NA) is a sialidase that contributes to viral mobility by removing the extracellular receptors for the haemagglutinin (HA) glycoprotein. However,...
