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  1. Pyrexia is the medical term for fever, in which the human body temperature rises above the average normal (37 degrees Celsius or 98.6 degrees Fahrenheit). Fever happens when the body's immune system responds to foreign invaders, such as bacteria, toxins, fungi, viruses, and even drugs.

  2. Oct 15, 2010 · Classic adult pyrexia of unknown origin is fever of 38.3°C or greater for at least 3 weeks with no identified cause after three days of hospital evaluation or three outpatient visits. Common causes are infections, neoplasms, and connective tissue disorders

    • George M Varghese, Paul Trowbridge, Tom Doherty
    • 2010
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  4. Oct 3, 2016 · Pyrexia (also named fever) is the altering upward of the thermoregulatory set point, often secondary to the systemic inflammatory response to a stimulus such as infection. The molecular basis is summarized in Fig. 1 [5, 6].

    • James F. Doyle, Frédérique Schortgen
    • 10.1186/s13054-016-1467-2
    • 2016
    • Crit Care. 2016; 20: 303.
  5. May 13, 2018 · This guide provides a structured approach to taking a history from a patient with pyrexia of unknown origin (PUO) in an OSCE setting. Download the PUO PDF OSCE checklist, or use our interactive OSCE checklist. You may also be interested in our infectious diseases articles.

  6. Sep 1, 2016 · Guidelines in critically ill adults define pyrexia as a temperature of 38.3 °C or greater, with the caveat that a lower threshold should be used in immunocompromised patients who are more likely to harbor a severe illness without significant elevation in body temperature . Although not a well-established inherited or acquired state of ...

    • Daniel J. Niven, Daniel J. Niven, Kevin B. Laupland
    • 10.1186/s13054-016-1406-2
    • 2016
    • Crit Care. 2016; 20(1): 247.
  7. Dec 29, 2017 · Since Hippokrates’ times, it has been known that fever and even more, hyperpyrexia in a potentially fatally ill neurocritical care patients, in particular in severe central nervous system (CNS) infections is detrimental, heralding poor prognosis, and adding to morbidity and mortality.

  8. COMMENT. About one week after the first dose of an MMR immunisation it is common to have symptoms of malaise, fever, and a rash, usually lasting 2–3 days. There is also an increased frequency of febrile convulsions at this time. These effects are likely to relate to the measles component and are less common after the second MMR immunisation. 1.

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