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Antibody-dependent enhancement
- Antibody-dependent enhancement (ADE) in dengue, a process mainly mediated by immunoglobulin G (IgG), is believed to be one of the major underlying mechanisms leading to increased severity in secondary DENV infection.
www.ncbi.nlm.nih.gov › pmc › articlesUnderstanding antibody-dependent enhancement in dengue: Are ...
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Mar 30, 2023 · Antibody-dependent enhancement (ADE) in dengue, a process mainly mediated by immunoglobulin G (IgG), is believed to be one of the major underlying mechanisms leading to increased severity in secondary DENV infection.
- 10.1371/journal.ppat.1011223
- 2023/03
- PLoS Pathog. 2023 Mar; 19(3): e1011223.
Jan 17, 2021 · Dengue virus (DENV) is an arbovirus transmitted mainly by Aedes aegypti and Aedes albopictus. It belongs to the genus Flavivirus of the Flaviviridae family and includes four serotypes (DENV 1–4). It causes asymptomatic infection, symptoms such as mild dengue fever, and even severe dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS).
- Guohui Cui, Lulu Si, Ying Wang, Junmei Zhou, Huijun Yan, Lifang Jiang
- 10.1002/jgm.3297
- 2021
- J Gene Med. 2021 Feb; 23(2): e3297.
- What Is Dengue?
- Who Gets Dengue?
- What Causes Dengue?
- What Are The Clinical Features of Dengue?
- What Are The Complications of Dengue?
- How Is Dengue Diagnosed?
- What Is The Differential Diagnosis For Dengue?
- What Is The Treatment of Dengue?
- Prevention of Dengue
Dengue, or dengue fever, is a viral illness transmitted by the bite of any of dengue viruses. Patients with dengue usually present with fever, headache, rash, nausea, vomiting, aches and pains. In some cases, dengue can progress to a severe form named severe dengue (previously known as dengue haemorrhagic fever), characterised by plasma leakage wit...
Several hundred years ago, dengue virus probably shifted from a mosquito-monkey-mosquito cycle of transmission to becoming endemicin humans. There are an estimated 400 million infectionsin more than 100 countries around the world every year, especially in tropical areas. Children, the elderly and immunosuppressed individuals tend to be more prone t...
Dengue virus belongs to the family of Flavivirus, the same family of viruses including yellow fever and zika. They are also called arboviruses, because are transmitted by arthropod bites (in the case of dengue by the Aedes mosquitoes, especially Aedes aegypti). Dengue viruses (DENV) are small, spherical, single-stranded enveloped RNAviruses with fo...
A person infected by the dengue virus develops severe flu-like symptoms. The clinical features of dengue fever vary according to the characteristics of the infected individual. Symptoms usually last for 2–7 days, after an incubationperiod of 4–10 days after the bite from an infected mosquito [1,3]. In 2009, WHO re-classified dengue infections as de...
The most feared complication of dengue is its severe form. Major bleeding, profound shock, multiple organ failure and brain or heart damage can usually lead to death when present. This is fortunately uncommon .
Dengue infection is diagnosed by testing blood samples during the first 5 days of symptoms and/or early recovery phase (more than 5 days of symptoms) confirming the presence of the virus. The diagnosis can also be confirmed by: 1. The presence of IgM against dengue virus (IgM is an antibodyproduced in acute infections); or; 2. The increase in IgG t...
This can be infectious (mostly) or non-infectious conditions. Infectious conditions 1. Viruses: chikungunya, zika, influenza, acute human immunodeficiency virus (HIV) infection, measles, rubella 2. Bacteria: leptospirosis, typhoid fever, typhus, bacterial sepsis, scarlet fever 3. Protozoa: malaria Non-infectious conditions 1. Inflammatory: systemic...
There is no specific treatment for dengue fever. Patients should seek medical advice, rest and drink plenty of fluids. 1. Paracetamol can be taken to bring down fever and reduce joint pains. 2. Aspirin or non-steroidal anti-inflammatories (NSAIDs) such as ibuprofen should not be taken since they can increase the risk of bleeding [1,5]. In the case ...
There is ongoing research about medications and vaccines against dengue virus, and also for reduction and/or elimination of Aedes mosquitoes [1,6].
May 14, 2024 · Key points. About 1 in 4 dengue virus infections are symptomatic. Approximately 1 in 20 patients with dengue progress to develop severe, life-threatening disease called severe dengue. Because there are four dengue viruses, people can be infected with DENV multiple times in their life. Clinical presentation.
Fever, headache, muscle and joint pain, rash. Can be severe, mild or asymptomatic [1] [2] Dengue fever is a mosquito-borne disease caused by dengue virus, prevalent in tropical and subtropical areas. It is frequently asymptomatic; if symptoms appear they typically begin 3 to 14 days after infection.
The most widely known ADE example occurs with dengue virus. Dengue is a single-stranded positive-polarity RNA virus of the family Flaviviridae. It causes disease of varying severity in humans, from dengue fever (DF), which is usually self-limited, to dengue hemorrhagic fever and dengue shock syndrome, either of which may be life-threatening.
Sometimes antibodies do not prevent cell entry and, on rare occasions, they may actually increase the ability of a virus to enter cells and cause a worsening of disease through a mechanism called antibody-dependent enhancement (ADE). What is ADE?
