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  1. Oct 25, 2022 · Clinical trials suggest doxyPEP would work to reduce STIs — although it’s only been proven in men who have sex with men. Doxycycline has plenty of street cred in the STI world.

  2. 6 days ago · In the past 5 years, studies have examined the potential of doxycycline as post-exposure prophylaxis (PEP) for STIs. Doxycycline is a broad-spectrum tetracycline, recommended as treatment for chlamydia and syphilis and is not recommended for gonorrhoea due to high levels of resistance.

  3. Apr 6, 2023 · The oral antibiotic doxycycline prevented the acquisition of sexually transmitted infections (STIs) when tested among men who have sex with men (MSM) and transgender women who took the medication within 72 hours of having condomless sex, according to findings published today in the New England Journal of Medicine.

  4. Doxycycline is FDA approved for treatment of STIs (e.g., chlamydia and syphilis) and prevention of other infections. The use of doxycycline for prevention of STIs as post-exposure prophylaxis is not currently included in national guidance.

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    • Amid Shortage of Bicillin, FDA to Import Another Syphilis Drug
    • Doxycycline Postexposure Prophylaxis Does Not Avert STIs in Women
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    MONDAY, Oct. 2, 2023 -- The U.S. Centers for Disease Control and Prevention is poised to recommend use of a powerful antibiotic to prevent sexually transmitted infections (STIs). On Monday, the CDC issued draft recommendations, recommending doctors consider prescribing doxycycline to help prevent the spread of disease.

    Dubbed Doxy-PEP -- short for doxycycline postexposure -- the approach calls for taking the antibiotic after a potential STI exposure rather than waiting until after a disease is diagnosed. If the draft recommendation is adopted, Doxy-PEP would be recommended for gay and bisexual men; other men who have sex with men; and transgender women who have been diagnosed with at least one STI caused by bacteria in the past year. Those infections include gonorrhea, chlamydia, or syphilis.

    The CDC is expected to advise doctors that prescribing a 200-mg dose of doxycycline "should be considered" for these patients within 72 hours after oral, vaginal, or anal sex. The agency needs more data before recommending it for other groups.

    The CDC is not the first to back this strategy. Health departments in California, Michigan, and New Mexico, among other agencies, already have guidance on Doxy-PEP.

    David Harvey, executive director of the National Coalition of STD Directors, hailed the proposed recommendation. "There is not a lot of money in STI care, prevention, and research," Harvey told CBS News. "So this development is profound for our field. And the community has already been working hard to implement Doxy-PEP and clinicians in some public health clinics are prescribing this widely."

    As part of the CDC draft recommendation, there is a request for doctors to assess side effects of Doxy-PEP and to screen every three to six months for breakthrough infections. "Larger evaluations can sometimes show negative outcomes that have been missed in smaller randomized trials," Jonathan Mermin, M.D., head of the CDC National Center for HIV, Viral Hepatitis, STD, and TB Prevention, said in an interview with CBS News. "So we are going to be continuing to monitor and evaluate the implementation of Doxy-PEP over time."

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    THURSDAY, Dec. 21, 2023 -- For Kenyan women receiving preexposure prophylaxis against HIV, the incidence of sexually transmitted infections (STIs) does not differ for those...

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    Antibiotics 101

  5. Jul 11, 2023 · The treatment – a form of post-exposure prophylaxis, or PEP – is a dose of the antibiotic doxycycline taken in the hours immediately after sex which works to extinguish an STI before it leads to...

  6. Oct 11, 2023 · The proposed guidelines state that a single 200mg dose of oral doxycycline taken within 72 hours after oral, anal or vaginal sex should be considered for gay, bisexual and other men who have sex with men and for transgender women who have had gonorrhoea, chlamydia or syphilis at least once during the past year.

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