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Sep 1, 2020 · Doxycycline is commonly dosed at 100 mg twice daily to treat bacterial infections and dermatologic conditions (e.g. acne vulgaris and rosacea). 3 Tetracyclines have both antiviral and anti-inflammatory properties that may ameliorate the response to viral infection. 3 – 6 Clinical studies indicate efficacy of doxycycline against dengue and chikun...
- Paul A. Yates, Steven A. Newman, Lauren J. Oshry, Robert H. Glassman, Ashton M. Leone, Elias Reichel
- 2020
Sep 21, 2021 · Bonzano et al14 confirmed that doxycycline at a dose of 200 mg daily in patients with COVID-19 administered for 8 days improved the sense of smell. This improvement was associated with the modulation of ACE2 and CD147 expression in the olfactory epithelium.
- Karolina Dorobisz, Tadeusz Dorobisz, Dariusz Janczak, Tomasz Zatoński
- 2021
Jun 6, 2020 · As doxycycline is inexpensive and widely available, has a safe tolerability profile, and is an attractive option for the treatment of COVID-19 as well as potentially alleviating the lung sequelae and also providing coverage against atypical bacterial pneumonia such as Mycoplasma pneumoniae and Legionella pneumophilia.
- Alexandre E. Malek, Bruno P. Granwehr, Dimitrios P. Kontoyiannis
- 2020
Other antibiotics currently under investigation include doxycycline, clarithromycin (Biaxin), and lincomycin (Lincocin), but the data on these or any other antibiotics were insufficient to include ...
Jul 27, 2021 · Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial - The Lancet Respiratory Medicine.
- Christopher C Butler, Ly-Mee Yu, Jienchi Dorward, Jienchi Dorward, Oghenekome Gbinigie, Gail Hayward...
- 2021
May 11, 2024 · Molnupiravir. The FDA has authorized an antiviral drug called molnupiravir. Molnupiravir treats mild to moderate COVID-19 in adults at higher risk of serious illness who can't take other treatments. The medication is taken by mouth as a pill. For people with COVID-19 who are in the hospital.
No safety issues were noted with use of doxycycline.Doxycycline is an attractive candidate as a repurposed drug in the treatment of COVID-19 infection, with an established safety profile, strong preclinical rationale, and compelling initial clinical experience described here.
