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  2. May 15, 2024 · Early recognition and treatment with doxycycline is critical to survival. Rocky Mountain spotted fever (RMSF) can be identified by a variety of tests. Always take a thorough patient history, including recent tick bites, exposure to areas where ticks are found, and travel history.

  3. By William A. Petri, Jr, MD, PhD, University of Virginia School of Medicine. Reviewed/Revised Jan 2024. Rocky Mountain spotted fever (RMSF) is caused by Rickettsia rickettsii and transmitted by ixodid ticks. Symptoms are high fever, severe headache, and rash. (See also Overview of Rickettsial and Related Infections.)

  4. Jul 17, 2023 · Currently, most cases of Rocky Mountain spotted fever are diagnosed based on immunoglobulin M (IgM) and IgG serologic responses to R. rickettsiae, in conjunction with a high degree of clinical suspicion. It is crucial to consider repeat testing after the resolution of symptoms, as serologic tests may be negative if testing occurs early in the ...

    • Jessica Snowden, Kari A. Simonsen
    • 2023/07/17
  5. Rocky Mountain spotted fever (RMSF), is the most severe rickettsiosis in the United States. RMSF is a rapidly progressive disease and without early administration of doxycycline can be fatal within days. Signs and symptoms may change as the illness progresses.

  6. Feb 16, 2024 · (See "Biology of Rickettsia rickettsii infection" and "Treatment of Rocky Mountain spotted fever".) PATHOGENESIS. The etiologic agent, R. rickettsii, is a gram-negative, obligate intracellular bacterium with a tropism for vascular endothelial cells.

  7. May 15, 2024 · Key points. The most common symptoms of Rocky Mountain spotted fever (RMSF) are a fever, headache, and rash. RMSF is spread through the bite of an infected tick. There is no vaccine to prevent RMSF. RMSF can be deadly if not treated early with doxycycline.

  8. Rocky Mountain spotted fever (RMSF) is a potentially lethal, but curable tick-borne disease, which was first described in Idaho in the 19 th century. In 1906, Howard Ricketts demonstrated that RMSF was an infectious disease transmitted by ticks [ 1 ]. The clinical spectrum of human infection ranges from mild to fulminant disease [ 2 ].