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  1. Mar 21, 2019 · Sepsis is a systemic response to infection, manifested by two or more of the SIRS criteria as a result of infection. Severe sepsis: Sepsis associated with organ dysfunction, hypoperfusion, or hypotension; hypoperfusion and perfusion abnormalities may include, but not limited to, lactic acidosis, oliguria, or an acute alteration in mental status

  2. Sep 9, 2018 · disappeared when adjusted for disease severity.3 This implies that the mortality in sepsis varies according to patient charac-teristics as well. A multicenter study in Australia and New Zealand that included 101,064 critical patients showed that the mortality rate in sepsis has decreased over the years from around 35% in 2000 to about 20% in 2012.1

  3. Feb 9, 2018 · better inform incidence, outcomes and research. The nature of sepsis is extremely complex, and the disease course can differ markedly between patients. As yet, sep-sis cannot be determined with certainty in many cases. Diagnosis often relies upon clinician gestalt as definitive microbiological evidence of a precipitating infection is often absent.

  4. The word, sepsis, is of Greek origin, first appearing in the epics of Homer, and denoting the rotting of flesh.3 Hippocrates (460–370 BCE) is generally credited with the first definition of sepsis. He postulated that living things die and decay through 1 of 2 processes. Sepsis was the process of death and decay associated with illness,

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