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  2. May 15, 2024 · Key points. The most common symptoms of Rocky Mountain spotted fever (RMSF) are a fever, headache, and rash. RMSF is spread through the bite of an infected tick. There is no vaccine to prevent RMSF. RMSF can be deadly if not treated early with doxycycline. What it is.

    • Clinical Care

      Key points. Doxycycline is the treatment of choice for RMSF...

    • What Is Rocky Mountain Spotted Fever?
    • Clinical Features of Rocky Mountain Spotted Fever
    • Skin Manifestations of Rocky Mountain Spotted Fever
    • Diagnosis of Rocky Mountain Spotted Fever
    • Treatment of Rocky Mountain Spotted Fever
    • Prevention of Rocky Mountain Spotted Fever

    Rocky Mountain spotted fever (RMSF) is a tick-borne infection caused by small bacteria called Rickettsia rickettsii. Various species of Dermacentor ticks are the typical vectors. Rickettsiae are introduced into humans after an infected tick is attached to the skin for at least 24 hours. RMSF occurs throughout the United States, Canada, Mexico, and ...

    Symptoms generally appear within 14 days of a tick bite. However the tick bite is painless and frequently goes unnoticed. The classic symptoms are fever, severe headache, and a rash. Fever and headache generally precede the rash by 2–5 days. Myalgias (muscle aches) are also common. Other symptoms that may be present include: 1. Gastrointestinal inv...

    Although the majority of patients with RMSF have a rash, in 4–26%, the rash is absent. 1. The rash initially appears as red macules(flat spots). The macules are 1–5mm in size and may be itchy. 2. Within days the lesions progress to become papules (small lumps), petechiae (small red or purple spots due to bleeding into the skin), and ecchymoses(brui...

    Early treatment reduces mortality, so the diagnosis of RMSF is often made based on clinical observations before the results of laboratory tests are available.
    Serology is the mainstay to confirm diagnosis of rickettsial diseases. These are blood tests that detect the presence of antibodies to rickettsial antigens. The indirect fluorescent antibodytest is...
    Organisms may be seen by direct immunofluorescence of skin biopsies, but false-negatives are common. So if clinical suspicion is high, treatment should commence even if the test is negative.

    Tetracyclines are the preferred treatment for RMSF. Doxycycline should be used for children of any age, including those less than 9 years old (the risk of stained teeth is outweighed by the improved efficacyof doxycycline in treating this potentially life-threatening disease). Chloramphenicol is an alternative drug and can be used to treat pregnant...

    Avoid areas such as forests or fields where ticks are found.
    Use DEET insect repellentson the skin, and permethrin on the clothes.
    Wear long-sleeved clothing that fits tightly around the wrists, waist, and ankles.
    Check twice daily for attached ticks and remove immediately. While wearing protective gloves, gently grasp the tick with tweezers as close as possible to the skin and slowly, gently pull it away.
  3. Jul 17, 2023 · Doxycycline is the drug of choice for the treatment of Rocky Mountain spotted fever, including in children. Defervescence typically occurs within three days of starting appropriate antibiotic therapy, although other symptoms may be slower to resolve.

    • Jessica Snowden, Kari A. Simonsen
    • 2023/07/17
  4. Mar 28, 2024 · We recommend empiric therapy with doxycycline for patients with suspected RMSF, even if symptoms are mild. Early therapy is critical since a delay in treatment is associated with an increased risk of mortality.

  5. Treatment |. Prevention |. Key Points |. More Information. Rocky Mountain spotted fever (RMSF) is caused by Rickettsia rickettsii and transmitted by ixodid ticks. Symptoms are high fever, severe headache, and rash. (See also Overview of Rickettsial and Related Infections.) Rocky Mountain spotted fever is a rickettsial disease. Epidemiology of RMSF.