Search results
The first person who was treated with streptomycin did not survive; the second person survived but became blind as a side effect of the treatment. In March 1946, the third person—Robert J. Dole, later Majority Leader of the United States Senate and presidential nominee—experienced a rapid and robust recovery.
Jul 4, 2023 · Streptomycin is the first discovered aminoglycoside antibiotic, originally isolated from the bacteria Streptomyces griseus. It is now primarily used as part of the multi-drug treatment of pulmonary tuberculosis. It has additional activity against several aerobic gram-negative bacteria. This activity will discuss the indications, mechanism of action, and contraindications of using streptomycin ...
- Mitchell Waters, Prasanna Tadi
- 2023/07/04
People also ask
Who discovered streptomycin?
When was streptococci first discovered?
Who are the streptomycin researchers?
The death rates associated with the disease also dropped off precipitously: while in 1930, 70 out of every 100,000 people in the United States died from the disease, by 1954 only 10 out of every 100,000 did. The advent of a cure greatly reduced the fears surrounding the disease and virtually ended the Sanatorium movement.
Streptomycin often required a 6-month treatment period to achieve a permanent cure of tuberculosis. That long time period resulted in the appearance of streptomycin-resistant Mycobacterium tuberculosis cells, caused by mutation. Then, especially in developing countries, due to the cost and inconvenience, many treatments were being shortened ...
- H. Boyd Woodruff
- 10.1128/AEM.01143-13
- 2014
- Appl Environ Microbiol. 2014 Jan; 80(1): 2-8.
streptomycin, antibiotic synthesized by the soil organism Streptomyces griseus. Streptomycin was discovered by American biochemists Selman Waksman, Albert Schatz, and Elizabeth Bugie in 1943. The drug acts by interfering with the ability of a microorganism to synthesize certain vital proteins. It was the first antimicrobial agent developed ...
- The Editors of Encyclopaedia Britannica
Sep 12, 2022 · Extending the linear part of the sigmoidal discovery curve in Figure 1 allows us to better define the Golden Age as 1943–1962, when streptomycin and the quinolones were discovered, respectively. A 2011 review in Clinical Microbiology Reviews defined the “discovery void”, during which no new antibiotic classes have been discovered, as ...
Feb 10, 2016 · In a following study, Kjems found that lysogeny was a common occurrence in group A streptococci and could be found in up to 83% of strains tested (Kjems, 1960). Transduction by streptococcal bacteriophages was first demonstrated by Leonard et al. of streptomycin resistance by several group A streptococcal phages (Leonard, Colón, & Cole, 1968).
