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- In 2018, IARC convened an Advisory Group to Recommend an Update to the Preamble to the IARC Monographs, with broad expertise across multiple disciplines, to consider progress in the scientific understanding of factors contributing to carcinogenicity as well as in the development of methods for information gathering, evidence assessment, and evidence integration.
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Sep 11, 2019 · This Commentary describes the motivation and methodology for the recent update to the Preamble to the IARC Monographs and highlights the key changes adopted. In addition, the methodology and utility of the hazard identifications provided by the Monographs are communicated more broadly.
- Abstract
- Motivation and Process For Preamble Revision
- Key Changes in The Revised Preamble
- Funding
- Notes
For nearly 50 years, the Monographs program of the International Agency for Research on Cancer (IARC) has been a premier global resource for identifying agents that can cause cancer. The identification of carcinogenic hazards is a necessary initial step in cancer prevention. National and international authorities and organizations use information o...
Since 2006, substantial growth has occurred in the scientific understanding of factors contributing to carcinogenicity as well as in the development of methods for information gathering, evidence assessment, and integration. In 2018, the IARC convened an “Advisory Group to Recommend an Update to the Preamble,” with broad expertise across multiple d...
General Procedures
The advisory group encouraged the IARC to clarify the purpose and scope of the Monographs evaluations. In this regard, the name of the Monographs series has been changed to the IARC Monographs on the Identification of Carcinogenic Hazards to Humans. This change, although semantic in nature, reflects the important distinction between hazard and risk: Hazard refers to the strength of the evidence that an agent is a carcinogen, whereas risk refers to the probability that a given exposure to a ca...
Scientific Review and Evaluation
The revised Preamble defines how the principles of systematic review (eg, formal consideration of quality of the studies, such as design and methodology, and the reporting of results that are tailored to each stream of evidence and the types of studies available) apply to IARC assessments and how evaluations are reached to clearly articulate the rationales for expert judgments. At the same time, it is designed to be flexible enough to enable incorporation of further scientific advances as the...
This work was supported by the German Ministry of Health and the International Agency for Research on Cancer.
The findings and conclusions in this article are those of the authors and do not necessarily represent the official position of the International Agency for Research on Cancer, the US Centers for Disease Control and Prevention, the US Food and Drug Administration, the US Environmental Protection Agency, or the US National Institute of Environmental...
- Jonathan M Samet, Weihsueh A Chiu, Vincent Cogliano, Jennifer Jinot, David Kriebel, Ruth M Lunn, Fre...
- 2020
The IARC Monographs programme celebrated its 50th anniversary between December 2021 and December 2022. The first IARC Monographs meeting took place on 13–17 December 1971 in Geneva, Switzerland, and the results were published with the distinctive orange cover as Volume 1 of the IARC Monographs on the Evaluation of the Carcinogenic Risk of ...
The principles, procedures, and scientific criteria that guide the evaluations are described in the Preamble to the IARC Monographs. Since 1971, more than 1000 agents have been evaluated, of which more than 500 have been identified as carcinogenic, probably carcinogenic, or possibly carcinogenic to humans.
The IARC Monographs on the Identification of Carcinogenic Hazards to Humans identify environmental factors that can increase the risk of human cancer. Interdisciplinary Working Groups of expert scientists review the published studies and evaluate the weight of the evidence.
The goal of the Monograph Programme is to assess carcinogenic hazards from occupational, environmental, and lifestyle exposures and agents, thus providing an essential step in the societal decision-making process to identify and then control carcinogenic hazards.
Jun 28, 2018 · (2022) 1,1,1-Trichloroethane and Four Other Industrial Chemicals Volume 129 (2022) Gentian Violet, Leucogentian Violet, Malachite Green, Leucomalachite Green, and CI Direct Blue 218
