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  1. May 16, 2024 · What are symptoms and health risks of xylazine? When used in people, xylazine can cause: Sedation. Difficulty breathing. Dangerously low blood pressure. Slowed heart rate. Wounds that can become infected. Severe withdrawal symptoms. Death. How are people exposed to xylazine?

  2. Xylazine-associated skin wounds can pose unique management challenges and may need specialized wound care. People who use xylazine may develop physiological dependence and have symptoms consistent with a xylazine-related substance use disorder.

  3. Jan 12, 2024 · 1% silver sulfadiazine (e.g., SilvadeneTM) has been a preferred topical therapy in caring for individuals with xylazine-associated wounds. Silver sulfadiazine is a prescription topical antibiotic that is often used in the treatment of burn wounds in outpatient and inpatient settings.

  4. Aug 19, 2022 · In this case report, we present a case of skin ulcers that were noticed in a PWID in the city of Philadelphia. We also hypothesize the presumed mechanism of skin injury and illustrate the latest trends in xylazine usage, its morbidity, and mortality trends all across the USA.

  5. Jun 14, 2023 · Abstract. A 32-year-old man presented with a 1-month history of enlarging chest wounds. He reported a history of daily injection of fentanyl adulterated with xylazine into his neck and arm...

  6. Aug 13, 2023 · The fentanyl-additive Xylazine causes open wounds, making the illegal drug supply even more dangerous and treatment more complicated.

  7. XYLAZINE WOUNDS. Wounds can appear whether you inject or not. They can happen anywhere on the body, not just at an injection site. Wounds can look like: • Blisters • Small purple bruises or scabs • “Pinpoint” holes in the skin • Large open sores • Dark or black pieces of dead skin Seek intervention by stage 2 if wound continues to ...

  8. Nov 29, 2023 · The veterinary sedative xylazine is spreading in unregulated opioid supplies across North America. Among people who use drugs with repeated exposure to xylazine, a distinct wound type has emerged. Here, we describe these wounds and share our experience treating them in a nurse-led, low-barrier wound care clinic in Philadelphia, PA.

  9. Apr 26, 2023 · There is an urgent need for more robust evidence on treatment options for acute xylazine intoxication, management of withdrawal symptoms, wound care, and long-term management of...

  10. Jan 2, 2024 · Xylazine-associated wounds and xylazine withdrawal reportedly act as significant barriers to care, including addiction treatment. Participants reported urgent need for scientific research and evidence-based guidance on the management of xylazine-associated wounds and withdrawal.

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