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   What causes Gilbert syndrome?

   • Learn more about Mayo Clinic’s use of data. Gilbert syndrome is caused by a modified gene you inherit from your parents. This gene usually controls an enzyme that helps break down bilirubin in your liver. When you have an ineffective gene, your blood contains excess amounts of bilirubin because your body doesn't produce enough of the enzyme.

   Gilbert syndrome - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org/diseases-conditions/gilberts-syndrome/symptoms-causes/syc-20372811

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   Is Gilbert's syndrome genetic?

   • Gilbert's syndrome is genetic, meaning it’s passed down from parent to child through a change, or mutation, in a gene. People with Gilbert's syndrome inherit a mutated UGT1A1 gene. What causes Gilbert's syndrome? A healthy UGT1A1 gene makes liver enzymes that break down bilirubin and remove it from the body.

   Gilbert's Syndrome: Symptoms, Causes, Tests & Treatment - Cleveland …

   my.clevelandclinic.org/health/diseases/17661-gilberts-syndrome

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   When was Gilbert syndrome first described?

   • The condition was first described in 1901 by Augustin Nicolas Gilbert. Gilbert syndrome produces an elevated level of unconjugated bilirubin in the bloodstream, but normally has no consequences. Mild jaundice may appear under conditions of exertion, stress, fasting, and infections, but the condition is otherwise usually asymptomatic.

   Gilbert's syndrome - Wikipedia

   en.wikipedia.org/wiki/Gilbert's_syndrome

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2. www.mayoclinic.org › diseases-conditions › gilbertsGilbert syndrome - Symptoms & causes - Mayo Clinic

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   Jul 1, 2022 · Symptoms. The most frequent sign of Gilbert syndrome is an occasional yellowish tinge of the skin and the whites of the eyes as a result of slightly higher levels of bilirubin in the blood. In people with Gilbert syndrome, bilirubin levels may increase due to: Illness, such as a cold or the flu. Fasting or eating a very low-calorie diet.

3. my.clevelandclinic.org › health › diseasesGilbert's Syndrome: Symptoms, Causes, Tests & Treatment

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   Jan 6, 2021 · Approximately 1 in 3 people with Gilbert's syndrome don’t have symptoms. They learn that they have the disease after getting blood tests to check for a different problem. Among those with symptoms, the most common sign is jaundice, brought on by elevated levels of bilirubin in blood. Jaundice can turn your skin and whites of the eyes yellow ...

4. www.healthline.com › health › gilberts-syndromeGilbert’s Syndrome: Symptoms, Causes, Diagnosis, and Treatment

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   Feb 9, 2018 · Gilbert's syndrome is a condition that affects how your body processes bilirubin. Learn more about its symptoms and the role of alcohol in this condition. ... We explain the causes, symptoms ...

5. www.ncbi.nlm.nih.gov › books › NBK470200Gilbert Syndrome - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov › books › NBK470200

   Feb 6, 2023 · Gilbert syndrome is an autosomal recessive disorder of bilirubin metabolism within the liver.[1][2] Reduced glucuronidation of bilirubin leads to unconjugated hyperbilirubinemia and recurrent episodes of jaundice.[1] Under normal circumstances, approximately 95% of bilirubin is unconjugated. Gilbert syndrome does not require treatment and must be distinguished from other disorders of ...

   • Published: 2023/02/06

6. www.webmd.com › children › what-is-gilbert-syndromeGilbert Syndrome: Causes, Symptoms, and More - WebMD

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   Aug 28, 2022 · Gilbert’s Syndrome Causes and Risk Factors It happens when a gene called UGT1A1 changes, or mutates. This gene carries instructions for making a liver enzyme that helps break down and get rid of ...

7. en.wikipedia.org › wiki › Gilbert's_syndromeGilbert's syndrome - Wikipedia

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   Gilbert syndrome ( GS) is a syndrome in which the liver of affected individuals processes bilirubin more slowly than the majority. [1] Many people never have symptoms. [1] Occasionally jaundice (a slight yellowish color of the skin or whites of the eyes) may occur. [1]

8. medlineplus.gov › genetics › conditionGilbert syndrome: MedlinePlus Genetics

   medlineplus.gov › genetics › condition

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   Gilbert syndrome is a relatively mild condition characterized by periods of elevated levels of a toxic substance called bilirubin in the blood (hyperbilirubinemia). Bilirubin, which has an orange-yellow tint, is produced when red blood cells are broken down. This substance is removed from the body only after it undergoes a chemical reaction in ...