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   What is progressive disease?

   • Physicians use many terms to describe the progress of a cancer or its response to treatment, one of which is progressive disease. Progressive disease means what the term implies, that a cancer is getting worse, but these terms are used to explain exactly how much worse a cancer appears to be.

   Progressive Disease and Cancer - Verywell Health

   www.verywellhealth.com/definition-of-progressive-disease-2249171

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   What is disease progression modeling?

   • Disease progression modeling involves the utilization of mathematical functions as quantitative descriptors of the time course of disease status. Disease models may incorporate biomarkers of disease severity and/or clinical outcomes to characterize the natural progression of disease.

   Disease Progression Modeling: Key Concepts and Recent Developments

   www.ncbi.nlm.nih.gov/pmc/articles/PMC5602534/

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   What is a progressive cancer?

   • With cancer, progressive disease is defined as at least a 20 percent growth in the size of the tumor or spread of the tumor since the beginning of treatment. In other words, if the size of a tumor is 20 percent larger on a scan it would be called progressive disease.

   Progressive Disease and Cancer - Verywell Health

   www.verywellhealth.com/definition-of-progressive-disease-2249171

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   What makes a tumor a progressive disease?

   • A tumor that is classified as being progressive disease has likely grown substantially or it would be called stable disease. Your tumor has spread to new regions or more evidence of cancer is seen in any area of previous spread. At the current time, the criteria for progression is likely changing.

   Progressive Disease and Cancer - Verywell Health

   www.verywellhealth.com/definition-of-progressive-disease-2249171

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2. www.verywellhealth.com › definition-of-progressiveProgressive Disease and Cancer - Verywell Health

   www.verywellhealth.com › definition-of-progressive

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   Nov 22, 2022 · Progressive disease is a term that describes a disease that is progressing or worsening. With cancer, progressive disease is defined as at least a 20 percent growth in the size of the tumor or spread of the tumor since the beginning of treatment. In other words, if the size of a tumor is 20 percent larger on a scan it would be called ...

3. www.ncbi.nlm.nih.gov › pmc › articlesClinical endpoints in oncology - a primer - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Apr 15, 2021 · Duration of clinical benefit (DoCB) is defined as the time from randomization to disease progression or death in patients who achieve complete response, partial response, or stable disease for 24 weeks or longer . It is a primary endpoint that is used in clinical trials in which disease stabilization in order to prolong survival is the primary ...

   • Author: Amanda Delgado, Achuta Kumar Guddati
   • Publication: Am J Cancer Res. 2021; 11(4): 1121-1131.

   • Publish Year: 2021
   • Published: 2021

4. www.ncbi.nlm.nih.gov › pmc › articlesWhen Progressive Disease Does Not Mean Treatment Failure ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Oct 10, 2012 · Progression, as described in the World Health Organization (WHO) guidelines of 1981 , is akin to cancer recurrence but is “usually reserved for patients with advanced disease.” Because response and progression play two very different roles in solid tumor oncology, the two may be better conceptualized as distinct events rather than the two ...

   • Author: Geoffrey R. Oxnard, Michael J. Morris, F. Stephen Hodi, Laurence H. Baker, Mark G. Kris, Alan P. Ven...
   • DOI: 10.1093/jnci/djs353

   • Publish Year: 2012
   • Published: 2012/10/10

5. www.ncbi.nlm.nih.gov › pmc › articlesDisease Progression Modeling: Key Concepts and Recent ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Disease progression modeling involves the utilization of mathematical functions as quantitative descriptors of the time course of disease status. Disease models may incorporate biomarkers of disease severity and/or clinical outcomes to characterize the natural progression of disease.

   • Author: Sarah F. Cook, Sarah F. Cook, Robert R. Bies, Robert R. Bies, Robert R. Bies
   • DOI: 10.1007/s40495-016-0066-x

   • Publish Year: 2016
   • Published: 2016/10

6. link.springer.com › chapter › 10What Is Disease Progression? | SpringerLink

   link.springer.com › chapter › 10

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   Jan 1, 2012 · How does the clinician know whether a patient with MS has progressive disease? In a similar way to the initial diagnosis of MS, although paraclinical measures and biomarkers (imaging and otherwise) can help, the diagnosis of progressive disease still remains firmly a clinical one.

7. www.nature.com › articles › s41571/023/00823-5Progression-free survival, disease-free survival and other ...

   www.nature.com › articles › s41571/023/00823-5

   Oct 12, 2023 · Progression-free survival (PFS), disease-free survival (DFS), relapse-free survival (RFS) and event-free survival (EFS) are among the most common end points used in oncology...