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  1. Between 1915 and 1926, an epidemic of encephalitis lethargica spread around the world. The exact number of people infected is unknown, but it is estimated that more than one million people contracted the disease during the epidemic, which directly caused more than 500,000 deaths.

  2. Jul 14, 2017 · Whereas many cases of encephalitis lethargica likely went unreported, it is equally probable that encephalitis lethargica was over-diagnosed during the epidemic period based on the wide array of non-specific signs and lack of established diagnostic criteria.

    • Leslie A Hoffman, Joel A Vilensky
    • 2017
  3. Nov 28, 2023 · Encephalitis lethargica is a disease characterized by high fever, headache, double vision, delayed physical and mental response, and lethargy. An epidemic of encephalitis lethargica occurred from 1917 to 1928, but no recurrence of the epidemic has since been reported.

  4. Feb 12, 2018 · The encephalitis lethargica epidemic of 1916-1930 is estimated to have affected at least half a million people in Europe. The disease is documented to have spread throughout the world to afflict hundreds of thousands more. The cause of the strange illness still remains a mystery today.

  5. Jan 30, 2023 · Abstract. Encephalitis lethargica developed in epidemic from 1919 to 1926 in Europe and throughout the world. From the clinical point of view, the disturbances of consciousness and alertness and the possible outcomes of a postencephalitic Parkinsonism has attracted much attention.

  6. Sep 9, 2021 · When Constantin von Economo (an Austrian neuroanatomist) described a handful of acute cases of Encephalitis lethargica in 1917, he highlighted symptoms of fever, headache, ocular paralysis and extraordinary sleepiness.

  7. encephalitis lethargica, form of encephalitis that emerged in the early 20th century. An encephalitis lethargica epidemic occurred from 1915 to 1928. The disease was first described medically in 1917, though numerous possible forerunners dating back to the 16th century have been identified.

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