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Encephalitis lethargica is characterized by high fever, sore throat, headache, lethargy, double vision, delayed physical and mental response, sleep inversion and catatonia. [5] [10] In severe cases, patients may enter a coma -like state ( akinetic mutism ). [citation needed] .
Jul 14, 2017 · The chronic phase of encephalitis lethargica typically developed 1 to 5 years after the acute phase, but it could also follow immediately, or more than a decade later. One patient developed a postencephalitic syndrome 45 years after initial infection ( Sacks, 1990 ).
- Leslie A Hoffman, Joel A Vilensky
- 2017
In 1973 Oliver Sacks published Awakenings , a book describing his evaluation of the effects of L-DOPA on postencephalitic parkinsonian patients at a chronic care facility in New York City. Their initial favourable response was so dramatic, and was described so well, that in 1990 the book was made into an award-winning film of the same name with Robin Williams portraying Dr Sacks and Robert De ...
- Joel A Vilensky, Sid Gilman
- 2006
Dec 20, 2018 · When L-DOPA administration generated the awakenings in the patients who had survived the acute phase of encephalitis lethargica, some family members reacted negatively because their role of unique carer for every need of the patients was jeopardised by the unexpected, albeit temporary, recovery.
- Marco De Ambrogi
- 2019
Feb 1, 2004 · Parkinson’s disease, encephalitis lethargica, multiple sclerosis and amyotrophic lateral sclerosis patients all display two distinct types of symptoms. Some of these are due directly to a deficiency of dopamine and are quickly reduced by laevodihydroxyphenylalanine (L-DOPA).
- Harold D Foster, Abram Hoffer
- 2004
Jun 2, 2007 · Sacks's book Awakenings is a series of extraordinary case reports describing how patients trapped by parkinsonism were re-awakened by levodopa after decades of stupor and inertia. After the first world war, an epidemic of encephalitis lethargica started in Vienna and spread across the world.
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How does L-DOPA affect family members in encephalitis lethargica?
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Sep 9, 2021 · Despite extensive public health surveillance, British authorities routinely claimed that most cases likely went unreported and that encephalitis’ long-term sequelae — including chronic fatigue, insomnia, tremors, gait and ocular disturbances, and radical behavioural changes that contributed to juvenile delinquency — could emerge from mild acute ...
