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Oct 29, 2022 · Prescription weight-loss drugs that you can use for more than 12 weeks, called long-term use, lead to major weight loss compared with an inactive treatment that doesn't use medicine, called a placebo.
- Oral semaglutide. What it is: Oral semaglutide is a glucagon-like peptide-1 (GLP-1) agonist. It mimics the effects of GLP-1, a gut hormone that's involved in blood glucose (sugar) control, digestion, and appetite management.
- Orforglipron. What it is: Orforglipron is an oral GLP-1 agonist. Unlike injectable GLP-1 agonists, it’s made of chemicals — not peptides (amino acid chains).
- Danuglipron. What it is: Danuglipron is an oral GLP-1 pill. It works the same way as orforglipron. How it’s administered: Danuglipron is an oral tablet.
- APH-012. What it is: APH-012 is an oral medicine that imitates the metabolic effects of gastric bypass (weight loss) surgery. It’s a glucose pill that’s designed to stimulate certain parts of your small intestine.
Feb 15, 2024 · Learn about eight medications that can help you lose weight and keep it off, such as orlistat, liraglutide, and bupropion-naltrexone. Find out how they work, how effective they are, and what side effects and precautions to consider.
Apr 1, 2024 · Weight-loss pills are a convenient, needle-free option for people who need help losing unwanted body weight. Typically, people can lose up to 3% to 12% of their body weight while taking one of these medications. Prescription-only pills that are FDA approved for weight loss are summarized below.
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- Liraglutide (Saxenda) How it works: Liraglutide is the same drug as the type 2 diabetes drugs Sadenxa and Victoza. It mimics an intestinal hormone that tells the brain your stomach is full.
- Naltrexone HCl and bupropion (Contrave) How it works: Contrave is a combination of two FDA-approved drugs, naltrexone, and bupropion, in an extended-release formula.
- Orlistat (Xenical) How it works: Blocks your body from absorbing about a third of the fat you eat. When a doctor prescribes orlistat, it's called Xenical.
- Phentermine. How it works: Curbs your appetite. Your doctor may prescribe this under the names including Adipex or Suprenza. Approved for long-term use? No. It's approved for short-term use (a few weeks) only.
Jan 12, 2023 · 4 min read. The search for effective and safe weight loss treatment seems never-ending. But the newest anti-obesity medication, semaglutide, is still making waves more than a year after its 2021 approval by the U.S. Food and Drug Administration.
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Policy. “We now understand obesity isn’t a character flaw,” says W. Scott Butsch, MD, an obesity medicine specialist. “It’s a dysfunction of the complex system that controls body weight, which is largely based on genetics.”
